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    PolD1 DNA polymerase delta subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PolD1provided by FlyBase
    Official Full Name
    DNA polymerase delta subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0263600
    Locus tag
    Dmel_CG5949
    See related
    AllianceGenome:FB:FBgn0263600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    5949; CAA61369; CG5949; Dm Poldelta; Dmel\CG5949; DNA pol delta; DNA Pol Delta; dnapol delta; DNApol-delta; l(3)72Ac; Pol delta125; polD; Poldelta; Poldelta 125KDa; Poldelta125KDa
    Summary
    Enables 3'-5'-DNA exonuclease activity and DNA-directed DNA polymerase activity. Involved in DNA replication proofreading. Located in nucleoplasm. Part of delta DNA polymerase complex. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gut section; head epidermis primordium; and mesoderm. Orthologous to human POLD1 (DNA polymerase delta 1, catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PolD1 in Genome Data Viewer
    Location:
    72C1-72C1; 3-43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15984322..15987815, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15977422..15980915, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene brahma Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45446 Neighboring gene ADP ribosylation factor-like 1 Neighboring gene Huntingtin-interacting protein 14 Neighboring gene herzog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila DNA polymerase delta. Purification and characterization. Aoyagi N, et al. J Biol Chem, 1994 Feb 25. PMID 7907087
    2. DNA polymerase delta from embryos of Drosophila melanogaster. Chiang CS, et al. Proc Natl Acad Sci U S A, 1993 Oct 1. PMID 8415662, Free PMC Article
    3. Isolation and sequence determination of the cDNA encoding DNA polymerase delta from Drosophila melanogaster. Chiang CS, et al. Gene, 1995 Dec 12. PMID 8543168
    4. Delta-type DNA polymerase characterized from Drosophila melanogaster embryos. Peck VM, et al. Nucleic Acids Res, 1992 Nov 11. PMID 1360647, Free PMC Article
    5. Purification of DNA polymerase-primase (DNA polymerase alpha) and DNA polymerase delta from embryos of Drosophila melanogaster. Mitsis PG, et al. Methods Enzymol, 1995. PMID 8594383

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in Drosophila the alternative TRF1/BRF complex appears responsible for the initiation of all known classes of Pol III transcription
      Title: Novel TRF1/BRF target genes revealed by genome-wide analysis of Drosophila Pol III transcription.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-DNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-DNA exonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication proofreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication proofreading IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair, gap-filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair, DNA gap filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of delta DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of delta DNA polymerase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase delta subunit 1
    Names
    CG5949-PA
    DNA polymerase delta
    DNA polymerase-delta
    DNA-polymerase-delta
    DNApol-delta
    PolD1-PA
    lethal (3) 72Ac
    NP_524099.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15984322..15987815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079375.3 → NP_524099.2  DNA polymerase delta subunit 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524099.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54358, Q9VUW8
      Related
      FBpp0075277
      Conserved Domains (4) summary
      cd05777
      Location:288 → 517
      DNA_polB_delta_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase delta, a family-B DNA polymerase
      cd05533
      Location:564 → 960
      POLBc_delta; DNA polymerase type-B delta subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. Presently, no direct data is available regarding ...
      PTZ00166
      Location:48 → 1092
      PTZ00166; DNA polymerase delta catalytic subunit; Provisional
      pfam14260
      Location:997 → 1070
      zf-C4pol; C4-type zinc-finger of DNA polymerase delta
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54358.2 P54358

    Gene LinkOut

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