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    Polr2K RNA polymerase II, I and III subunit K [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 5740790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Polr2Kprovided by FlyBase
    Official Full Name
    RNA polymerase II, I and III subunit Kprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262954
    Locus tag
    Dmel_CG34186
    See related
    AllianceGenome:FB:FBgn0262954
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG34186; Dmel\CG34186; Rpb12; RPB12; RPC10
    Summary
    Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase I activity; RNA polymerase II activity; and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Predicted to be part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Is expressed in several structures, including anterior endoderm; embryonic/larval midgut; embryonic/larval midgut primordium; and posterior endoderm. Orthologous to human POLR2K (RNA polymerase II, I and III subunit K). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Polr2K in Genome Data Viewer
    Location:
    51E2-51E2; 2-74 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15144968..15145519, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11032473..11033024, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44457 Neighboring gene charlatan Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assessment of the roles of Spt5-nucleic acid contacts in promoter proximal pausing of RNA polymerase II. Dollinger R, et al. J Biol Chem, 2023 Sep. PMID 37517697, Free PMC Article
    2. Identification of potential pathways and biomarkers linked to progression in ALS. Huber RG, et al. Ann Clin Transl Neurol, 2023 Feb. PMID 36533811, Free PMC Article
    3. In silico identification of Drosophila melanogaster genes encoding RNA polymerase subunits. Marygold SJ, et al. MicroPubl Biol, 2020 Oct 20. PMID 33274328, Free PMC Article
    4. Genes encoding Drosophila melanogaster RNA polymerase II general transcription factors: diversity in TFIIA and TFIID components contributes to gene-specific transcriptional regulation. Aoyagi N, et al. J Cell Biol, 2000 Jul 24. PMID 10908585, Free PMC Article
    5. An RNAi-mediated screen identifies novel targets for next-generation antiepileptic drugs based on increased expression of the homeostatic regulator pumilio. Lin WH, et al. J Neurogenet, 2018 Mar-Jun. PMID 29718742, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase I activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase II, I and III subunit K
    Names
    CG34186-PA
    Polr2K-PA
    Rpb12
    NP_001097319.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15144968..15145519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103849.3 → NP_001097319.1  RNA polymerase II, I and III subunit K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097319.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6IGE3
      Conserved Domains (1) summary
      smart00659
      Location:14 → 57
      RPOLCX; RNA polymerase subunit CX
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IGE3 Q6IGE3

    Gene LinkOut

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