Mrm2 Mitochondrial rRNA methyltransferase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Mrm2provided by FlyBase
Official Full Name: Mitochondrial rRNA methyltransferase 2provided by FlyBase
Primary source: FLYBASE:FBgn0038737
Locus tag: Dmel_CG11447
See related: AllianceGenome:FB:FBgn0038737
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11447; Dmel\CG11447; DmMRM2
Summary: Predicted to enable rRNA (uridine-2'-O-)-methyltransferase activity. Involved in mitochondrial large ribosomal subunit assembly. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Used to study mitochondrial DNA depletion syndrome 17. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 17. Orthologous to human MRM2 (mitochondrial rRNA methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (19861610..19862600)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (15687332..15688322)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables rRNA (uridine-2'-O-)-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA (uridine-2'-O-)-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA methylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA methylation	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial large ribosomal subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial matrix	IC Inferred by Curator more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

NP_650835.1

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The following sections contain reference sequences that belong to a specific genome build. Explain