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    Ir68a Ionotropic receptor 68a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ir68aprovided by FlyBase
    Official Full Name
    Ionotropic receptor 68aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036150
    Locus tag
    Dmel_CG6185
    See related
    AllianceGenome:FB:FBgn0036150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    68a; CG6185; CT19410; DmelIR68a; Dmel\CG6185; IR68a
    Summary
    Predicted to enable ligand-gated monoatomic ion channel activity. Predicted to be involved in detection of chemical stimulus. Predicted to be located in membrane. Is expressed in several structures, including adult antennal lobe receptor neurons; external compound sense organ; organism subdivision; synaptic neuropil domain; and synaptic neuropil subdomain. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ir68a in Genome Data Viewer
    Location:
    68B3-68B3; 3-35 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11232972..11236218, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11226072..11229318, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46050 Neighboring gene long non-coding RNA:CR45405 Neighboring gene long non-coding RNA:CR44718 Neighboring gene long non-coding RNA:CR44719 Neighboring gene long non-coding RNA:CR44714 Neighboring gene long non-coding RNA:CR44713

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Connectomics Analysis Reveals First-, Second-, and Third-Order Thermosensory and Hygrosensory Neurons in the Adult Drosophila Brain. Marin EC, et al. Curr Biol, 2020 Aug 17. PMID 32619476, Free PMC Article
    2. Early Integration of Temperature and Humidity Stimuli in the Drosophila Brain. Frank DD, et al. Curr Biol, 2017 Aug 7. PMID 28736172, Free PMC Article
    3. Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila. Knecht ZA, et al. Elife, 2017 Jun 16. PMID 28621663, Free PMC Article
    4. Synchronous and opponent thermosensors use flexible cross-inhibition to orchestrate thermal homeostasis. Hernandez-Nunez L, et al. Sci Adv, 2021 Aug. PMID 34452914, Free PMC Article
    5. Humidity response depends on the small soluble protein Obp59a in Drosophila. Sun JS, et al. Elife, 2018 Sep 19. PMID 30230472, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ionotropic receptor 68a
    Names
    CG6185-PA
    CG6185-PB
    Ir68a-PA
    Ir68a-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11232972..11236218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300102.1 → NP_001287031.1  ionotropic receptor 68a, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287031.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JCB2
      Conserved Domains (1) summary
      pfam00060
      Location:429 → 660
      Lig_chan; Ligand-gated ion channel

    2. NM_140198.3 → NP_648455.2  ionotropic receptor 68a, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648455.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VTH3
      Conserved Domains (1) summary
      pfam00060
      Location:429 → 661
      Lig_chan; Ligand-gated ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VTH3 Q9VTH3
    X2JCB2 X2JCB2

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