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    Acph-1 Acid phosphatase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 48445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acph-1provided by FlyBase
    Official Full Name
    Acid phosphatase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0000032
    Locus tag
    Dmel_CG7899
    See related
    AllianceGenome:FB:FBgn0000032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ACP; Acph; ACPH; APH; CG7899; Dmel\CG7899
    Summary
    Enables acid phosphatase activity. Predicted to be located in extracellular exosome and nucleus. Is expressed in adult heart and germline cell. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J and prostate cancer. Orthologous to several human genes including ACP2 (acid phosphatase 2, lysosomal) and ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Acph-1 in Genome Data Viewer
    Location:
    99D1-99D1; 3-100 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29991144..29993411, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25816866..25819133, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tachykinin-like receptor at 99D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spindle assembly abnormal 6 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of male reproductive behavior by the central nervous system of Drosophila: dissection of a courtship pathway by genetic mosaics. Hall JC. Genetics, 1979 Jun. PMID 114447, Free PMC Article
    2. Purification and characterization of acid phosphatase-1 from Drosophila melanogaster. Feigen MI, et al. J Biol Chem, 1980 Nov 10. PMID 6776114
    3. Sub-units of acid phosphatase-1 in Drosophila melanogaster: reversible dissociation in vitro. MacIntyre RJ, et al. Nature, 1967 Apr 15. PMID 6034240
    4. The genetics of an acid phosphatase in Drosophila melanogaster and Drosophila simulans. MacIntyre R. Genetics, 1966 Mar. PMID 5919327, Free PMC Article
    5. Induction of null-activity mutants for the acid phosphatase-1 gene in Drosophila melanogaster. Bell JB, et al. Biochem Genet, 1972 Apr. PMID 4199799

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acid phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    acid phosphatase 1
    Names
    Acph-1-PA
    Acph-1-PB
    CG7899-PA
    CG7899-PB
    acid Phosphatase-1
    acid phosphatase
    NP_524917.1
    NP_733332.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29991144..29993411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080178.5 → NP_524917.1  acid phosphatase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524917.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAD0
      Related
      FBpp0084974
      Conserved Domains (1) summary
      cd07061
      Location:47 → 344
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

    2. NM_170453.2 → NP_733332.1  acid phosphatase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8I0P9
      Related
      FBpp0084975
      Conserved Domains (1) summary
      cd07061
      Location:64 → 361
      HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I0P9 Q8I0P9
    Q9VAD0 Q9VAD0

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