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    dl dorsal [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35047, updated on 9-Dec-2024

    Summary

    Official Symbol
    dlprovided by FlyBase
    Official Full Name
    dorsalprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260632
    Locus tag
    Dmel_CG6667
    See related
    AllianceGenome:FB:FBgn0260632
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:GressD7; CG6667; dL; Dl; DL; Dmel\CG6667; Dor; Dorsal; fs(2)k10816; GSd447; mat(2)dorsal; NF-kappaB; NF-KB; NFkappaB; p65
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and high mobility group box 1 binding activity. Involved in several processes, including Toll signaling pathway; positive regulation of hemocyte proliferation; and positive regulation of macromolecule biosynthetic process. Located in several cellular components, including cytosol; neuromuscular junction; and subsynaptic reticulum. Is expressed in several structures, including adult head; embryonic/larval hypodermal muscle cell; epithelium; germline cell; and neuromuscular junction. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; primary immunodeficiency disease; and renal cell carcinoma. Orthologous to several human genes including RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    Location:
    36C8-36C9; 2-53 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (17436830..17450364, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (17436830..17450364, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46204 Neighboring gene uncharacterized protein Neighboring gene Serine protease homolog 93

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Toll signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Toll signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dorsal/ventral axis specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in dorsal/ventral pattern formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dorsal/ventral pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in melanization defense response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in non-canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peripheral nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of antimicrobial peptide production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hemocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hemocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of hemocyte proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cytokine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in subsynaptic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dorsal
    Names
    CG6667-PA
    CG6667-PB
    CG6667-PC
    CG6667-PD
    CG6667-PE
    CG6667-PF
    DORSAL
    Dorsal/NF-kappaB
    NFkappabeta
    dl-PA
    dl-PB
    dl-PC
    dl-PD
    dl-PE
    dl-PF
    embryonic polarity protein dorsal

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      17436830..17450364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165217.3NP_724052.1  dorsal, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHK3
      Related
      FBpp0080558
      Conserved Domains (2) summary
      cd07887
      Location:47220
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      cd01177
      Location:225326
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    2. NM_165218.3NP_724053.1  dorsal, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724053.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHK3
      Related
      FBpp0080559
      Conserved Domains (2) summary
      cd07887
      Location:47220
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      cd01177
      Location:225326
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    3. NM_001169530.1NP_001163001.1  dorsal, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163001.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHK3
      Conserved Domains (2) summary
      cd07887
      Location:47220
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      cd01177
      Location:225326
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    4. NM_001169529.1NP_001163000.1  dorsal, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JHK3
      Conserved Domains (2) summary
      cd07887
      Location:47220
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      cd01177
      Location:225326
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    5. NM_165219.2NP_724054.1  dorsal, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724054.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77088, P15330, Q0E8P9, Q6AWP3, Q9VJD9, Q9VJE0
      UniProtKB/TrEMBL
      C7LA93
      Related
      FBpp0080560
      Conserved Domains (2) summary
      cd07887
      Location:47220
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      cd01177
      Location:225326
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
    6. NM_001299085.1NP_001286014.1  dorsal, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286014.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O77088, P15330, Q0E8P9, Q6AWP3, Q9VJD9, Q9VJE0
      UniProtKB/TrEMBL
      C7LA93
      Conserved Domains (2) summary
      cd07887
      Location:47220
      RHD-n_Dorsal_Dif; N-terminal sub-domain of the Rel homology domain (RHD) of the arthropod protein Dorsal
      cd01177
      Location:225326
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...