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    Lime Linking immunity and metabolism [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36023, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Limeprovided by FlyBase
    Official Full Name
    Linking immunity and metabolismprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033458
    Locus tag
    Dmel_CG18446
    See related
    AllianceGenome:FB:FBgn0033458
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18446; Dmel\CG18446
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval hemocyte; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Lime in Genome Data Viewer
    Location:
    46C1-46C1; 2-61 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9871470..9873646)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5758975..5761151)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45138 Neighboring gene pendolino Neighboring gene N-terminal methyltransferase Neighboring gene uncharacterized protein Neighboring gene Secretory 24AB Neighboring gene antisense RNA:CR45467 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple Independent Retroelement Insertions in the Promoter of a Stress Response Gene Have Variable Molecular and Functional Effects in Drosophila. Merenciano M, et al. PLoS Genet, 2016 Aug. PMID 27517860, Free PMC Article
    2. The Interplay Between Developmental Stage and Environment Underlies the Adaptive Effect of a Natural Transposable Element Insertion. Merenciano M, et al. Mol Biol Evol, 2023 Mar 4. PMID 36811953, Free PMC Article
    3. Lime is a new protein linking immunity and metabolism in Drosophila. Mihajlovic Z, et al. Dev Biol, 2019 Aug 15. PMID 31085193
    4. A unique cluster of roo insertions in the promoter region of a stress response gene in Drosophila melanogaster. Merenciano M, et al. Mob DNA, 2019. PMID 30911338, Free PMC Article
    5. Regulating gene expression in the Drosophila germ line. Rangan P, et al. Cold Spring Harb Symp Quant Biol, 2008. PMID 19270081

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    linking immunity and metabolism
    Names
    CG18446-PA
    Lime-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9871470..9873646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136685.3 → NP_610529.1  linking immunity and metabolism [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610529.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JZC5
      Related
      FBpp0087464
      Conserved Domains (1) summary
      sd00017
      Location:317 → 336
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JZC5 Q7JZC5

    Gene LinkOut

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