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    Pgant2 Polypeptide N-Acetylgalactosaminyltransferase 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33556, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgant2provided by FlyBase
    Official Full Name
    Polypeptide N-Acetylgalactosaminyltransferase 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031530
    Locus tag
    Dmel_CG3254
    See related
    AllianceGenome:FB:FBgn0031530
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3254; Dmel\CG3254; DmGalNAc-T2; pgant2; PGANT2
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in oligosaccharide biosynthetic process and protein O-linked glycosylation via threonine. Predicted to be active in Golgi apparatus. Is expressed in several structures, including adult head; central brain primordium; clypeo-labral disc primordium; embryonic ventral epidermis; and epidermis. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human GALNT2 (polypeptide N-acetylgalactosaminyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgant2 in Genome Data Viewer
    Location:
    23F1-23F1; 2-10 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3404460..3426719, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3404460..3426719, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44791 Neighboring gene antisense RNA:testis-specific 15 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Sorting nexin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigation of sequon engineering for improved O-glycosylation by the human polypeptide N-acetylgalactosaminyl transferase T2 isozyme and two orthologues. Thompson NK, et al. Biochem J, 2021 Oct 15. PMID 34523671
    2. Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase ortholog pairs. Gerken TA, et al. Glycobiology, 2008 Nov. PMID 18669915, Free PMC Article
    3. Deep data mining reveals variable abundance and distribution of microbial reproductive manipulators within and among diverse host species. Medina P, et al. PLoS One, 2023. PMID 37432953, Free PMC Article
    4. Expression of the UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase family is spatially and temporally regulated during Drosophila development. Tian E, et al. Glycobiology, 2006 Feb. PMID 16251381
    5. Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster. Ten Hagen KG, et al. J Biol Chem, 2003 Sep 12. PMID 12829714

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oligosaccharide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via threonine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi stack NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polypeptide N-Acetylgalactosaminyltransferase 2
    Names
    CG3254-PA
    CG3254-PB
    Pgant2-PA
    Pgant2-PB
    polypeptide GalNAc transferase 2
    NP_608773.2
    NP_995625.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3404460..3426719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205903.3 → NP_995625.2  polypeptide N-Acetylgalactosaminyltransferase 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995625.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6WV19, Q7KU27, Q7YU21, Q9VQQ2
      Conserved Domains (4) summary
      cd02510
      Location:205 → 500
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:200 → 432
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:513 → 629
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:511 → 627
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_134929.4 → NP_608773.2  polypeptide N-Acetylgalactosaminyltransferase 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608773.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q6WV19, Q7KU27, Q7YU21, Q9VQQ2
      Conserved Domains (4) summary
      cd02510
      Location:205 → 500
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:200 → 432
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:513 → 629
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:511 → 627
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6WV19.2 Q6WV19

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