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    muskelin muskelin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36386, updated on 9-Dec-2024

    Summary

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    Official Symbol
    muskelinprovided by FlyBase
    Official Full Name
    muskelinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033757
    Locus tag
    Dmel_CG8811
    See related
    AllianceGenome:FB:FBgn0033757
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8811; Dmel\CG8811; DmMK; Muskelin
    Summary
    Involved in oocyte maturation and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of GID complex. Is expressed in organism. Orthologous to human MKLN1 (muskelin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See muskelin in Genome Data Viewer
    Location:
    49B10-49B10; 2-67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12628697..12632378, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8516202..8519883, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spt4 Neighboring gene uncharacterized protein Neighboring gene Mevalonate kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition. Kronja I, et al. Proc Natl Acad Sci U S A, 2014 Nov 11. PMID 25349405, Free PMC Article
    2. Characterization of a Drosophila melanogaster orthologue of muskelin. Adams JC. Gene, 2002 Sep 4. PMID 12384287
    3. The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition. Zavortink M, et al. Elife, 2020 Jun 23. PMID 32573431, Free PMC Article
    4. A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. Shao W, et al. PLoS One, 2010 Apr 1. PMID 20368978, Free PMC Article
    5. Proteomic Analysis of Red Ginseng on Prolonging the Life Span of Male Drosophila melanogaster. Hou W, et al. Front Pharmacol, 2021. PMID 34177563, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell-matrix adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    muskelin
    Names
    CG8811-PA
    CG8811-PB
    CG8811-PC
    muskelin-PA
    muskelin-PB
    muskelin-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12628697..12632378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273992.1 → NP_001260921.1  muskelin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFH1, Q8MR83
      Conserved Domains (4) summary
      smart00668
      Location:240 → 292
      CTLH; C-terminal to LisH motif
      sd00038
      Location:299 → 349
      Kelch; KELCH repeat [structural motif]
      pfam06588
      Location:44 → 241
      Muskelin_N; Muskelin N-terminus
      pfam13418
      Location:299 → 341
      Kelch_4; Galactose oxidase, central domain

    2. NM_136957.3 → NP_610801.1  muskelin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610801.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9A5, Q8MR83
      Related
      FBpp0086999
      Conserved Domains (4) summary
      smart00668
      Location:240 → 292
      CTLH; C-terminal to LisH motif
      sd00038
      Location:299 → 350
      Kelch; KELCH repeat [structural motif]
      pfam06588
      Location:44 → 241
      Muskelin_N; Muskelin N-terminus
      pfam13415
      Location:313 → 362
      Kelch_3; Galactose oxidase, central domain

    3. NM_165928.1 → NP_725200.1  muskelin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725200.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9A5, Q8MR83
      Related
      FBpp0086998, FBtr0087885
      Conserved Domains (4) summary
      smart00668
      Location:240 → 292
      CTLH; C-terminal to LisH motif
      sd00038
      Location:299 → 350
      Kelch; KELCH repeat [structural motif]
      pfam06588
      Location:44 → 241
      Muskelin_N; Muskelin N-terminus
      pfam13415
      Location:313 → 362
      Kelch_3; Galactose oxidase, central domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFH1 A0A0B4KFH1
    Q0E9A5 Q0E9A5
    Q8MR83 Q8MR83
    Q8WSN1 Q8WSN1

    Gene LinkOut

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