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    CG4945 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36850, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4945provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034137
    Locus tag
    Dmel_CG4945
    See related
    AllianceGenome:FB:FBgn0034137
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT15864; Dmel\CG4945; PKN
    Summary
    Predicted to enable protein serine/threonine kinase activity. Is expressed in dorsal pharyngeal muscle cell; larval muscle system; and larval somatic muscle cell. Orthologous to several human genes including SBK1 (SH3 domain binding kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4945 in Genome Data Viewer
    Location:
    53C8-53C8; 2-80 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16566023..16570120)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12453528..12457625)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Syntrophin-like 2 Neighboring gene Dopamine transporter Neighboring gene Ribosomal protein S15 Neighboring gene uncharacterized protein Neighboring gene Limostatin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Predicting spatial and temporal gene expression using an integrative model of transcription factor occupancy and chromatin state. Wilczynski B, et al. PLoS Comput Biol, 2012. PMID 23236268, Free PMC Article
    2. Mes2, a MADF-containing transcription factor essential for Drosophila development. Zimmermann G, et al. Dev Dyn, 2006 Dec. PMID 17029287
    3. A high throughput, functional screen of human Body Mass Index GWAS loci using tissue-specific RNAi Drosophila melanogaster crosses. Baranski TJ, et al. PLoS Genet, 2018 Apr. PMID 29608557, Free PMC Article
    4. Patterns of gene expression during Drosophila mesoderm development. Furlong EE, et al. Science, 2001 Aug 31. PMID 11486054
    5. Functional relevance of genes predicted to be affected by epigenetic alterations in atypical teratoid/rhabdoid tumors. Tegeder I, et al. J Neurooncol, 2019 Jan. PMID 30446899

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mesoderm development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4945-PA
    CG4945-PB
    CG4945-PC
    CG4945-PD
    NP_001286492.1
    NP_725590.1
    NP_788382.1
    NP_788383.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16566023..16570120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166182.3 → NP_725590.1  uncharacterized protein Dmel_CG4945, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725590.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SZT8, Q9V7R1
      Related
      FBpp0086245
      Conserved Domains (2) summary
      COG0515
      Location:25 → 358
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd13987
      Location:32 → 293
      STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

    2. NM_176203.3 → NP_788383.1  uncharacterized protein Dmel_CG4945, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788383.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAH6
      Related
      FBpp0086247
      Conserved Domains (2) summary
      COG0515
      Location:25 → 358
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd13987
      Location:32 → 293
      STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

    3. NM_176202.3 → NP_788382.1  uncharacterized protein Dmel_CG4945, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAH6
      Related
      FBpp0086246
      Conserved Domains (2) summary
      COG0515
      Location:25 → 358
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd13987
      Location:32 → 293
      STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1

    4. NM_001299563.1 → NP_001286492.1  uncharacterized protein Dmel_CG4945, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286492.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFM3
      Conserved Domains (2) summary
      COG0515
      Location:25 → 358
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd13987
      Location:32 → 293
      STKc_SBK1; Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFM3 A0A0B4LFM3
    A1ZAH6 A1ZAH6
    Q8SZT8 Q8SZT8

    Gene LinkOut

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