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    ste24b ste24b prenyl protease type I [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36907, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ste24bprovided by FlyBase
    Official Full Name
    ste24b prenyl protease type Iprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034175
    Locus tag
    Dmel_CG9001
    See related
    AllianceGenome:FB:FBgn0034175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9001; Dmel\CG9001; Dmel\Ste24; Dmel\Ste24b
    Summary
    Predicted to enable metalloendopeptidase activity. Involved in spermatogenesis. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in mandibuloacral dysplasia type B lipodystrophy; restrictive dermopathy; and restrictive dermopathy 1. Orthologous to human ZMPSTE24 (zinc metallopeptidase STE24). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ste24b in Genome Data Viewer
    Location:
    53E4-53E4; 2-81 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16998610..17000126, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12886115..12887631, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44377 Neighboring gene Calbindin 53E Neighboring gene uncharacterized protein Neighboring gene ste24c prenyl protease type I Neighboring gene prenyl protease type I Neighboring gene Asparaginyl-tRNA synthetase, mitochondrial Neighboring gene Nuclear inhibitor of Protein phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Type-I prenyl protease function is required in the male germline of Drosophila melanogaster. Adolphsen K, et al. G3 (Bethesda), 2012 Jun. PMID 22690372, Free PMC Article
    2. Population genomics of Wolbachia and mtDNA in Drosophila simulans from California. Signor S. Sci Rep, 2017 Oct 17. PMID 29042606, Free PMC Article
    3. An ABC transporter controls export of a Drosophila germ cell attractant. Ricardo S, et al. Science, 2009 Feb 13. PMID 19213920, Free PMC Article
    4. Selection, recombination and demographic history in Drosophila miranda. Bachtrog D, et al. Genetics, 2006 Dec. PMID 17028331, Free PMC Article
    5. Wun2-mediated integrin recycling promotes apoptotic cell clearance in Drosophila melanogaster. Gao N, et al. Cell Death Differ, 2022 Dec. PMID 35840760, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CAAX-box protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CAAX-box protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ste24b prenyl protease type I
    Names
    CG9001-PA
    prenyl protease type I
    ste24b-PA
    NP_611174.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16998610..17000126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137330.1 → NP_611174.1  ste24b prenyl protease type I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611174.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAM7, Q8IHA2
      Related
      FBpp0086208, FBtr0087060
      Conserved Domains (3) summary
      COG0501
      Location:167 → 444
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam01435
      Location:220 → 444
      Peptidase_M48; Peptidase family M48
      pfam16491
      Location:35 → 214
      Peptidase_M48_N; CAAX prenyl protease N-terminal, five membrane helices
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAM7 A1ZAM7
    Q8IHA2 Q8IHA2

    Gene LinkOut

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