Chsy Chondroitin sulfate synthase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Chsyprovided by FlyBase
Official Full Name: Chondroitin sulfate synthaseprovided by FlyBase
Primary source: FLYBASE:FBgn0030662
Locus tag: Dmel_CG9220
See related: AllianceGenome:FB:FBgn0030662
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9220; dCHSY; Dmel\CG9220
Summary: Predicted to enable N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Predicted to be located in Golgi cisterna membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Orthologous to human CHSY1 (chondroitin sulfate synthase 1) and CHSY3 (chondroitin sulfate synthase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (15585289..15593534, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (15479322..15487567, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables acetylgalactosaminyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chondroitin sulfate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondroitin sulfate proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info

NP_001285280.1

NP_996440.2

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The following sections contain reference sequences that belong to a specific genome build. Explain