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    Pdh Photoreceptor dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdhprovided by FlyBase
    Official Full Name
    Photoreceptor dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011693
    Locus tag
    Dmel_CG4899
    See related
    AllianceGenome:FB:FBgn0011693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4899; Dmel\CG4899; pcdr; pdh; PDH
    Summary
    Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in retinal metabolic process and retinol metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pdh in Genome Data Viewer
    Location:
    72E2-72E2; 3-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16353233..16354297, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16346333..16347397, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Methionine-CAT 1-4 Neighboring gene mitochondrial ribosomal protein S34 Neighboring gene Golgin 104 Neighboring gene antisense RNA:CR45894 Neighboring gene Threonyl-carbamoyl synthesis 3 Neighboring gene ringmaker Neighboring gene Cuticular protein 72Ea

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family. Hofmann L, et al. Biochemistry, 2016 Nov 29. PMID 27809489, Free PMC Article
    2. Vision: the retinoid cycle in Drosophila. Arshavsky VY. Curr Biol, 2010 Feb 9. PMID 20144777
    3. The Drosophila visual cycle and de novo chromophore synthesis depends on rdhB. Wang X, et al. J Neurosci, 2012 Mar 7. PMID 22399771, Free PMC Article
    4. pcdr, a novel gene with sexually dimorphic expression in the pigment cells of the Drosophila eye. Brunel CA, et al. Dev Genes Evol, 1998 Aug. PMID 9716723, Free PMC Article
    5. Requirement for an enzymatic visual cycle in Drosophila. Wang X, et al. Curr Biol, 2010 Jan 26. PMID 20045325, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of photoreceptor retinol dehydrogenase (PDH) activity leads to photoreceptor degeneration.
      Title: Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.
    2. Retinol dehydrogenase B is expressed in retinal pigment cells, where it promotes the final enzymatic reaction necessary for production of the chromophore.
      Title: The Drosophila visual cycle and de novo chromophore synthesis depends on rdhB.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in retinal metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retinol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    photoreceptor dehydrogenase
    Names
    CG4899-PA
    CG4899-PB
    CG4899-PC
    CG4899-PD
    Pdh-PA
    Pdh-PB
    Pdh-PC
    Pdh-PD
    photoreceptor retinol dehydrogenase
    pigment cell dehydrogenase reductase
    pigment-cell-enriched dehydrogenase
    NP_001137959.1
    NP_001137960.1
    NP_524105.2
    NP_730153.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16353233..16354297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168659.2 → NP_730153.1  photoreceptor dehydrogenase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730153.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQN8
      Related
      FBpp0075185
      Conserved Domains (2) summary
      pfam00106
      Location:23 → 213
      adh_short; short chain dehydrogenase
      cl21454
      Location:23 → 258
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_079381.3 → NP_524105.2  photoreceptor dehydrogenase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524105.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O96646, Q9VV42
      Related
      FBpp0075184
      Conserved Domains (2) summary
      pfam00106
      Location:23 → 214
      adh_short; short chain dehydrogenase
      cl21454
      Location:23 → 259
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001144487.2 → NP_001137959.1  photoreceptor dehydrogenase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KNR7
      Conserved Domains (2) summary
      pfam00106
      Location:6 → 197
      adh_short; short chain dehydrogenase
      cl21454
      Location:6 → 242
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. NM_001144488.2 → NP_001137960.1  photoreceptor dehydrogenase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137960.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z061
      Conserved Domains (2) summary
      pfam00106
      Location:6 → 196
      adh_short; short chain dehydrogenase
      cl21454
      Location:6 → 241
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z061 B7Z061
    Q7KNR7 Q7KNR7
    Q8IQN8 Q8IQN8
    Q9VV42 Q9VV42

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