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    Arp1 Actin-related protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41566, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arp1provided by FlyBase
    Official Full Name
    Actin-related protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0011745
    Locus tag
    Dmel_CG6174
    See related
    AllianceGenome:FB:FBgn0011745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Actr87C; Arp; arp-1; Arp-1; arp1; ARP1; Arp87c; Arp87C; ARP87C; CG6174; Dmel\CG6174; gdl; grid
    Summary
    Involved in anterograde axonal transport; axonal transport of mitochondrion; and retrograde axonal transport. Predicted to be part of dynactin complex. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut primordium; ganglia; and gut section. Orthologous to several human genes including ACTR1A (actin related protein 1A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Arp1 in Genome Data Viewer
    Location:
    87C5-87C5; 3-52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12691743..12694232)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8517465..8519954)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene karmoisin Neighboring gene Suppressor of fused Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ninjurin C Neighboring gene Putative Achaete Scute Target 1 Neighboring gene uncharacterized protein Neighboring gene DNA polymerase theta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genes encoding actin-related proteins of Drosophila melanogaster. Fyrberg C, et al. J Mol Biol, 1994 Aug 19. PMID 8064864
    2. Actin' like actin? Mullins RD, et al. Trends Cell Biol, 1996 Jun. PMID 15157457
    3. Dynactin is necessary for synapse stabilization. Eaton BA, et al. Neuron, 2002 May 30. PMID 12062020
    4. The actin-related proteins. Frankel S, et al. Curr Opin Cell Biol, 1996 Feb. PMID 8791406
    5. Symmetry breaking in the female germline cyst. Nashchekin D, et al. Science, 2021 Nov 12. PMID 34762476, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A missense mutation in the dynactin Arp1 subunit causes most oskar mRNA to localise in the posterior cytoplasm rather than cortically.
      Title: Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte.
    2. Results show that dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment.
      Title: Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anterograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonal transport of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in retrograde axonal transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of dynactin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Actin-related protein 1
    Names
    Actin-related protein 87C
    Arp1-PA
    CG6174-PA
    actin related protein 1
    gridlock

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12691743..12694232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079607.3 → NP_524331.2  Actin-related protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524331.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45889, Q9VG37
      Related
      FBpp0082121
      Conserved Domains (2) summary
      smart00268
      Location:9 → 376
      ACTIN; Actin
      cl17037
      Location:5 → 376
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45889.2 P45889

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