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    Prosbeta4R2 Proteasome beta4 subunit-related 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33451, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosbeta4R2provided by FlyBase
    Official Full Name
    Proteasome beta4 subunit-related 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031443
    Locus tag
    Dmel_CG17302
    See related
    AllianceGenome:FB:FBgn0031443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0140519.122; beta4R2; CG17302; Dmel\CG17302
    Summary
    Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosbeta4R2 in Genome Data Viewer
    Location:
    23A2-23A2; 2-7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2655394..2657102)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2655394..2657102)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Proteasome beta4 subunit-related 1 Neighboring gene Odorant receptor 23a Neighboring gene TBP-related factor 4 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteasome Structure and Assembly. Budenholzer L, et al. J Mol Biol, 2017 Nov 10. PMID 28583440, Free PMC Article
    2. Expression of proteasome subunit isoforms during spermatogenesis in Drosophila melanogaster. Ma J, et al. Insect Mol Biol, 2002 Dec. PMID 12421421
    3. Lethality in Drosophila melanogaster/Drosophila simulans species hybrids is not associated with substantial transcriptional misregulation. Barbash DA, et al. J Exp Zool B Mol Dev Evol, 2007 Jan 15. PMID 17075830
    4. Duplicated proteasome subunit genes in Drosophila and their roles in spermatogenesis. Belote JM, et al. Heredity (Edinb), 2009 Jul. PMID 19277057
    5. Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy. Sakata E, et al. Proc Natl Acad Sci U S A, 2012 Jan 31. PMID 22215586, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    NOT enables peptidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasomal protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome beta4 subunit-related 2
    Names
    CG17302-PA
    CG17302-PB
    Prosbeta4R2-PA
    Prosbeta4R2-PB
    proteasome beta4R2 subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2655394..2657102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273021.1 → NP_001259950.1  proteasome beta4 subunit-related 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259950.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRP4, Q9VQE5
      UniProtKB/TrEMBL
      M9PE80
      Conserved Domains (2) summary
      COG0638
      Location:1 → 194
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03758
      Location:3 → 194
      proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    2. NM_164491.3 → NP_722823.2  proteasome beta4 subunit-related 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722823.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRP4, Q9VQE5
      UniProtKB/TrEMBL
      M9PE80
      Related
      FBpp0077383
      Conserved Domains (2) summary
      COG0638
      Location:1 → 194
      PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
      cd03758
      Location:3 → 194
      proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PE80 M9PE80
    Q9VQE5.3 Q9VQE5

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