EDTP Egg-derived tyrosine phosphatase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: EDTPprovided by FlyBase
Official Full Name: Egg-derived tyrosine phosphataseprovided by FlyBase
Primary source: FLYBASE:FBgn0027506
Locus tag: Dmel_CG6542
See related: AllianceGenome:FB:FBgn0027506
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.124; BcDNA:LD23181; CG6542; D-EDTP; Dmel\CG6542
Summary: Predicted to enable phosphatidylinositol-3-phosphate phosphatase activity. Involved in oogenesis. Is expressed in nurse cell; oocyte; and organism. Human ortholog(s) of this gene implicated in centronuclear myopathy 1. Orthologous to human MTMR14 (myotubularin related protein 14). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 54B7-54B15; 2-82 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (17432173..17444938, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (13319678..13332443, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

demonstrate a novel approach of tissue-specific downregulation of the disease-associated gene EDTP/MTMR14 for extended lifespan and improved survival to cellular protein aggregates.
Title: EDTP/MTMR14: A novel target for improved survivorship to prolonged anoxia and cellular protein aggregates.
Downregulation of egg-derived tyrosine phosphatase in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster.
Title: Downregulation of EDTP in glial cells suppresses polyglutamine protein aggregates and extends lifespan in Drosophila melanogaster.
EDTP in muscle appears to be critical for regulating systemic ageing.
Title: Egg-derived tyrosine phosphatase as a potential biomarker for muscle ageing and degeneration in Drosophila melanogaster.
EDTP gene is crucial in oogenesis and embryogenesis.
Title: Involvement of EDTP, an egg-derived tyrosine phosphatase, in the early development of Drosophila melanogaster.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables phosphatidylinositol-3-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: Egg-derived tyrosine phosphatase

Names: CG6542-PA; CG6542-PC; EDTP-PA; EDTP-PC

NP_523770.2

EC 3.1.3.-

EC 3.1.3.64

NP_995873.2

EC 3.1.3.-

EC 3.1.3.64

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

17432173..17444938 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079046.3 → NP_523770.2 Egg-derived tyrosine phosphatase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523770.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9NDR1

Related

FBpp0086114

Conserved Domains (2) summary

cd13213
Location:215 → 341

PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cl21483
Location:366 → 445

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_206151.2 → NP_995873.2 Egg-derived tyrosine phosphatase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995873.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZAS8

Conserved Domains (2) summary

cd13213
Location:215 → 341

PH-GRAM_MTMR14; Myotubularian (MTM) related 14 protein (MTMR14) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

cl21483
Location:366 → 445

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...