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    kri krishah [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kriprovided by FlyBase
    Official Full Name
    krishahprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035639
    Locus tag
    Dmel_CG5537
    See related
    AllianceGenome:FB:FBgn0035639
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey275; CG5537; Dmel\CG5537; uprt
    Summary
    Enables uracil phosphoribosyltransferase activity. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; fat body; larval somatic muscle cell; and mesoderm. Orthologous to human UPRT (uracil phosphoribosyltransferase homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kri in Genome Data Viewer
    Location:
    64E11-64E11; 3-15 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5810973..5812228)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5804073..5805328)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Tektin C Neighboring gene Ribosomal protein S6 kinase Neighboring gene uncharacterized protein Neighboring gene mad2 Neighboring gene vein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Flies without a spindle checkpoint. Buffin E, et al. Nat Cell Biol, 2007 May. PMID 17417628
    2. The Genetic Basis of Natural Variation in Drosophila melanogaster Immune Defense against Enterococcus faecalis. Chapman JR, et al. Genes (Basel), 2020 Feb 22. PMID 32098395, Free PMC Article
    3. UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan. Ghosh AC, et al. Sci Rep, 2015 Aug 14. PMID 26271729, Free PMC Article
    4. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. Doumanis J, et al. PLoS One, 2009 Sep 30. PMID 19789644, Free PMC Article
    5. Steroid Signaling Establishes a Female Metabolic State and Regulates SREBP to Control Oocyte Lipid Accumulation. Sieber MH, et al. Curr Biol, 2015 Apr 20. PMID 25802149, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We find that the Drosophila UPRT homologue, krishah (kri), codes for an enzyme that is required for larval growth, pre-pupal/pupal viability and long-term adult lifespan.
      Title: UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables uracil phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    krishah
    Names
    CG5537-PA
    CG5537-PB
    CG5537-PC
    kri-PA
    kri-PB
    kri-PC
    NP_001261451.1
    NP_001261452.1
    NP_647990.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5810973..5812228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274523.1 → NP_001261452.1  krishah, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261452.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRQ1
      Conserved Domains (1) summary
      pfam14681
      Location:70 → 260
      UPRTase; Uracil phosphoribosyltransferase

    2. NM_139733.2 → NP_647990.1  krishah, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647990.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRQ1
      Related
      FBpp0076818, FBtr0077112
      Conserved Domains (1) summary
      pfam14681
      Location:70 → 260
      UPRTase; Uracil phosphoribosyltransferase

    3. NM_001274522.1 → NP_001261451.1  krishah, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261451.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHI7
      Conserved Domains (1) summary
      pfam14681
      Location:70 → 245
      UPRTase; Uracil phosphoribosyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHI7 M9PHI7
    Q9VRQ1 Q9VRQ1

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