U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gr64a Gustatory receptor 64a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117481, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gr64aprovided by FlyBase
    Official Full Name
    Gustatory receptor 64aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0045479
    Locus tag
    Dmel_CG32261
    See related
    AllianceGenome:FB:FBgn0045479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14986; CG32261; Dmel64a; Dmel\CG32261; Gr64; GR64a; Gr64A1; GRLU.3; GrLU3; LU.3
    Summary
    Enables ionotropic sweet taste receptor activity and sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of taste; proboscis extension reflex; and sensory perception of sweet taste. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adult brain; labral sense organ neurons; organism subdivision; posterior superior lateral protocerebrum; and wing disc. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gr64a in Genome Data Viewer
    Location:
    64A4-64A4; 3-10 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4026769..4028600)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4026769..4028600)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Forkhead box L1 Neighboring gene Mitochondrial E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized protein Neighboring gene Gustatory receptor 64c Neighboring gene Gustatory receptor 64b Neighboring gene Gustatory receptor 64d Neighboring gene Gustatory receptor 64e Neighboring gene antisense RNA:CR45042

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster. Nishimura A, et al. J Neurogenet, 2012 Jun. PMID 22794108
    2. Structural basis for sugar perception by Drosophila gustatory receptors. Ma D, et al. Science, 2024 Feb 23. PMID 38305684
    3. Enterococci Mediate the Oviposition Preference of Drosophila melanogaster through Sucrose Catabolism. Liu W, et al. Sci Rep, 2017 Oct 18. PMID 29044155, Free PMC Article
    4. Secondary taste neurons that convey sweet taste and starvation in the Drosophila brain. Kain P, et al. Neuron, 2015 Feb 18. PMID 25661186
    5. Taste-independent detection of the caloric content of sugar in Drosophila. Dus M, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21709242, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here we sought to decipher the genes required for fructose response among Gr64a-Gr64f genes. Unexpectedly, the qPCR analyses for these genes show that labellar expression levels of Gr64d and Gr64e are higher in fructose low-sensitivity flies than in high-sensitivity flies
      Title: Deciphering the Genes for Taste Receptors for Fructose in Drosophila.
    2. The results of this study showed that the starvation-induced functional change in the taste sensory system and expression of a sugar taste receptor expression.
      Title: Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster.
    3. Gr5a and Gr64a are each capable of functioning independently of each other within individual sugar neurons and that they are the primary receptors used in the labellum to detect sugars.(Gr64a protein, Drosophila)
      Title: Two Gr genes underlie sugar reception in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ionotropic sweet taste receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sweet taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sweet taste receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables taste receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables taste receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detection of chemical stimulus involved in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of taste IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proboscis extension reflex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sweet taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sweet taste IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory perception of sweet taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of taste NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    gustatory receptor 64a
    Names
    CG32261-PA
    Gr64a-PA
    gustatory receptor LU.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4026769..4028600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168048.2 → NP_728920.1  gustatory receptor 64a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728920.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P83293, Q9VZJ7
      Related
      FBpp0073050
      Conserved Domains (1) summary
      pfam06151
      Location:48 → 452
      Trehalose_recp; Trehalose receptor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P83293.1 P83293

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools