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    CtsK2 Cathepsin K2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CtsK2provided by FlyBase
    Official Full Name
    Cathepsin K2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034229
    Locus tag
    Dmel_CG4847
    See related
    AllianceGenome:FB:FBgn0034229
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH19547; CG4847; CTS K; Cts3; Cts4; Dmel\CG4847
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Involved in sexual reproduction. Located in extracellular space. Is expressed in adult head; adult heart; embryonic ventral epidermis; and sensory nervous system primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CtsK2 in Genome Data Viewer
    Location:
    54C1-54C1; 2-83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17511513..17513855)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13399018..13401360)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene narrow Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Anaphase Promoting Complex subunit 10 Neighboring gene patronin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional conservation profiles of novel cathepsin L-like proteins identified in the Drosophila melanogaster genome. Kumar S, et al. J Biomol Struct Dyn, 2013 Dec. PMID 23256878
    2. Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting. Wittkopp PJ, et al. Genetics, 2006 Jul. PMID 16702434, Free PMC Article
    3. Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster. Giardina TJ, et al. Mol Ecol, 2011 Oct. PMID 21902747, Free PMC Article
    4. The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll Pathway. Issa N, et al. Mol Cell, 2018 Feb 15. PMID 29452635, Free PMC Article
    5. A dual role of lola in Drosophila ovary development: regulating stem cell niche establishment and repressing apoptosis. Zhao T, et al. Cell Death Dis, 2022 Sep 2. PMID 36056003, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sexual reproduction HEP PubMed 
    involved_in sexual reproduction IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cathepsin K2
    Names
    CG4847-PA
    CG4847-PC
    CG4847-PD
    CG4847-PE
    CtsK2-PA
    CtsK2-PC
    CtsK2-PD
    CtsK2-PE
    cathepsinK
    NP_611221.1
    NP_725686.1
    NP_725688.1
    NP_995874.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17511513..17513855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137377.3 → NP_611221.1  cathepsin K2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611221.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K5N8
      Related
      FBpp0086089
      Conserved Domains (2) summary
      cd02248
      Location:174 → 388
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:82 → 142
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    2. NM_166235.2 → NP_725686.1  cathepsin K2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725686.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAU4
      Related
      FBpp0086091
      Conserved Domains (2) summary
      cd02248
      Location:204 → 418
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:112 → 172
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    3. NM_166237.2 → NP_725688.1  cathepsin K2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725688.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K5N8
      Related
      FBpp0086090
      Conserved Domains (2) summary
      cd02248
      Location:174 → 388
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:82 → 142
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

    4. NM_206152.2 → NP_995874.1  cathepsin K2, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995874.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K5N8
      Conserved Domains (2) summary
      cd02248
      Location:174 → 388
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
      pfam08246
      Location:82 → 142
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAU4 A1ZAU4
    Q7K5N8 Q7K5N8

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