Dpm1 Dolichyl-phosphate mannosyltransferase subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dpm1provided by FlyBase
Official Full Name: Dolichyl-phosphate mannosyltransferase subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0032799
Locus tag: Dmel_CG10166
See related: AllianceGenome:FB:FBgn0032799
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10166; dDPM; Dmel\CG10166; Dol-P-ManTase; DPM1
Summary: Predicted to enable dolichyl-phosphate beta-D-mannosyltransferase activity and metal ion binding activity. Predicted to be involved in GPI anchor biosynthetic process; dolichol metabolic process; and protein glycosylation. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ie. Orthologous to human DPM1 (dolichyl-phosphate mannosyltransferase subunit 1, catalytic). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19525434..19526368, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19525434..19526368, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables dolichyl-phosphate beta-D-mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dolichyl-phosphate beta-D-mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables dolichyl-phosphate beta-D-mannosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in dolichol-linked oligosaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dolichol-linked oligosaccharide biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked mannosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein glycosylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of dolichol-phosphate-mannose synthase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

NP_609980.1

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The following sections contain reference sequences that belong to a specific genome build. Explain