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    Ssl1 Suppressor of stem-loop mutation [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40509, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssl1provided by FlyBase
    Official Full Name
    Suppressor of stem-loop mutationprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037202
    Locus tag
    Dmel_CG11115
    See related
    AllianceGenome:FB:FBgn0037202
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11115; Dmel\CG11115; p44; ssl1; SSL1
    Summary
    Predicted to enable zinc ion binding activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Is expressed in organism. Orthologous to human GTF2H2C (GTF2H2 family member C); GTF2H2C_2 (GTF2H2 family member C, copy 2); and GTF2H2 (general transcription factor IIH subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ssl1 in Genome Data Viewer
    Location:
    80B2-80B2; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22879089..22880963)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22872189..22874063)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor 1 Neighboring gene antisense RNA:CR45968 Neighboring gene uncharacterized protein Neighboring gene Chromator Neighboring gene antisense RNA:CR45970 Neighboring gene slimfast Neighboring gene long non-coding RNA:CR44688

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chromator, a novel and essential chromodomain protein interacts directly with the putative spindle matrix protein skeletor. Rath U, et al. J Cell Biochem, 2004 Nov 15. PMID 15389869
    2. The chromodomain protein, Chromator, interacts with JIL-1 kinase and regulates the structure of Drosophila polytene chromosomes. Rath U, et al. J Cell Sci, 2006 Jun 1. PMID 16723739
    3. DNA repair and transcriptional deficiencies caused by mutations in the Drosophila p52 subunit of TFIIH generate developmental defects and chromosome fragility. Fregoso M, et al. Mol Cell Biol, 2007 May. PMID 17339330, Free PMC Article
    4. A Drosophila XPD model links cell cycle coordination with neuro-development and suggests links to cancer. Stettler K, et al. Dis Model Mech, 2015 Jan. PMID 25431422, Free PMC Article
    5. Using qualitative probability in reverse-engineering gene regulatory networks. Ibrahim ZM, et al. IEEE/ACM Trans Comput Biol Bioinform, 2011 Mar-Apr. PMID 20876933

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA polymerase II promoter clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in transcription open complex formation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    suppressor of stem-loop mutation
    Names
    CG11115-PA
    CG11115-PB
    Ssl1-PA
    Ssl1-PB
    suppressor of Stem-Loop mutation ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22879089..22880963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141170.3 → NP_649427.1  suppressor of stem-loop mutation, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNP8
      Related
      FBpp0078205
      Conserved Domains (3) summary
      pfam04056
      Location:67 → 258
      Ssl1; Ssl1-like
      COG5151
      Location:10 → 407
      SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
      cl06838
      Location:291 → 403
      C1_4; TFIIH C1-like domain

    2. NM_001275298.1 → NP_001262227.1  suppressor of stem-loop mutation, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262227.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNP8
      Conserved Domains (3) summary
      pfam04056
      Location:67 → 258
      Ssl1; Ssl1-like
      COG5151
      Location:10 → 407
      SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
      cl06838
      Location:291 → 403
      C1_4; TFIIH C1-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNP8 Q9VNP8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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