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    CG41128 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG41128provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0069923
    Locus tag
    Dmel_CG41128
    See related
    AllianceGenome:FB:FBgn0069923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH61753; Dmel\CG41128; Minos1b; RH61753p
    Summary
    Enables structural molecule activity. Involved in cristae formation. Part of MICOS complex. Is expressed in adult head; adult heart; and organism. Orthologous to human MICOS10 (mitochondrial contact site and cristae organizing system subunit 10). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG41128 in Genome Data Viewer
    Location:
    81F5-81F5; 3-47.1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (3750363..3752353)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3RHet NW_001848858.1 (1806528..1808518, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46141 Neighboring gene Translocase of the inner mitochondrial membrane 17b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs. Laver JD, et al. Cell Rep, 2020 Mar 10. PMID 32160542
    2. Drosophila MIC10b can polymerize into cristae-shaping filaments. Stephan T, et al. Life Sci Alliance, 2024 Apr. PMID 38253420, Free PMC Article
    3. Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD. Li S, et al. Cell Rep, 2020 Aug 4. PMID 32755582, Free PMC Article
    4. The asymmetrically segregating lncRNA cherub is required for transforming stem cells into malignant cells. Landskron L, et al. Elife, 2018 Mar 27. PMID 29580384, Free PMC Article
    5. Evolution and structural organization of the mitochondrial contact site (MICOS) complex and the mitochondrial intermembrane space bridging (MIB) complex. Huynen MA, et al. Biochim Biophys Acta, 2016 Jan. PMID 26477565

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in inner mitochondrial membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MICOS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MICOS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG41128-PB
    mitochondrial INner membrane organizing system 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      3750363..3752353
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001015402.3 → NP_001015402.3  uncharacterized protein Dmel_CG41128 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001015402.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJS0, Q8SY69
      Conserved Domains (1) summary
      pfam04418
      Location:2 → 69
      DUF543; Domain of unknown function (DUF543)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SY69 Q8SY69

    Gene LinkOut

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