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    Atf3 Activating transcription factor 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Atf3provided by FlyBase
    Official Full Name
    Activating transcription factor 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0028550
    Locus tag
    Dmel_CG11405
    See related
    AllianceGenome:FB:FBgn0028550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A3-3; atf3; ATF3; CG11405; dATF3; DM11; Dmel\CG11405; EG:33C11.1
    Summary
    Enables sequence-specific DNA binding activity. Involved in immune response; lipid homeostasis; and regulation of lipid storage. Located in nucleus. Is expressed in several structures, including epithelium; ganglia; gland; gut section; and larval imaginal tissue. Orthologous to several human genes including ATF3 (activating transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Atf3 in Genome Data Viewer
    Location:
    1E5-1F1; 1-0.1 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1242740..1275284, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1136773..1169317, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dishevelled Associated Activator of Morphogenesis Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An accelerated miRNA-based screen implicates Atf-3 in Drosophila odorant receptor expression. Bhat S, et al. Sci Rep, 2016 Feb 5. PMID 26848073, Free PMC Article
    2. The molecular basis of bacterial-insect symbiosis. Douglas AE. J Mol Biol, 2014 Nov 25. PMID 24735869, Free PMC Article
    3. Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. Sekyrova P, et al. Development, 2010 Jan. PMID 20023169, Free PMC Article
    4. An Orthologous Epigenetic Gene Expression Signature Derived from Differentiating Embryonic Stem Cells Identifies Regulators of Cardiogenesis. Busser BW, et al. PLoS One, 2015. PMID 26485529, Free PMC Article
    5. Eater cooperates with Multiplexin to drive the formation of hematopoietic compartments. Csordás G, et al. Elife, 2020 Oct 7. PMID 33026342, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. provide a mechanism to explain how an ATF3-Raw module controls JNK signalling to maintain normal intestinal barrier function during acute infection
      Title: ATF3 acts as a rheostat to control JNK signalling during intestinal regeneration.
    2. Atf3 controls the microtubule network and plays important role in cell differentiation and cell polarity.
      Title: Atf3 links loss of epithelial polarity to defects in cell differentiation and cytoarchitecture.
    3. Loss of Atf3 results in chronic inflammation and starvation responses mounted primarily by the larval gut epithelium, while the fat body suffers lipid overload, causing energy imbalance and death.
      Title: Activating transcription factor 3 regulates immune and metabolic homeostasis.
    4. Data thus identify Atf3 as a new functional partner of Drosophila Jun during development.
      Title: Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    activating transcription factor 3
    Names
    A3-3
    Atf3-PA
    Atf3-PB
    Atf3-PC
    CG11405-PA
    CG11405-PB
    CG11405-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      1242740..1275284 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297840.1 → NP_001284769.1  activating transcription factor 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284769.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRE5, Q9XZS8
      Conserved Domains (1) summary
      cd14722
      Location:215 → 268
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

    2. NM_138988.4 → NP_620473.1  activating transcription factor 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_620473.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MRE5, Q9XZS8
      Related
      FBpp0070234
      Conserved Domains (1) summary
      cd14722
      Location:215 → 268
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain

    3. NM_001272196.2 → NP_001259125.1  activating transcription factor 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259125.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PIP2
      Conserved Domains (1) summary
      cd14722
      Location:215 → 268
      bZIP_ATF3; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-3 (ATF-3) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PIP2 M9PIP2
    Q9XZS8.1 Q9XZS8

    Gene LinkOut

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