Dp DP transcription factor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dpprovided by FlyBase
Official Full Name: DP transcription factorprovided by FlyBase
Primary source: FLYBASE:FBgn0011763
Locus tag: Dmel_CG4654
See related: AllianceGenome:FB:FBgn0011763
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 49Fk; CG4654; dDp; dDP; dDP1; DDP1; DmDP; Dmel\CG4654; dp; DP; Dp1; DP1; l(2)49Fk; l(2)vr10; TFPD2; vr10
Summary: Enables DNA binding activity and DNA-binding transcription factor binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including dorsal/ventral axis specification, ovarian follicular epithelium; intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of nurse cell apoptotic process. Located in nucleus. Part of Myb complex and Rb-E2F complex. Is expressed in several structures, including embryonic/larval midgut primordium; epithelium; ganglia; imaginal disc; and mesoderm. Human ortholog(s) of this gene implicated in mismatch repair cancer syndrome. Orthologous to several human genes including TFDP1 (transcription factor Dp-1) and TFDP2 (transcription factor Dp-2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 49F10-49F11; 2-68 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13222433..13228202)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9109938..9115707)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings identify a key function of E2F/Dp in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
Title: E2F function in muscle growth is necessary and sufficient for viability in Drosophila.
results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
Title: RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.
Dampened transcriptional activation by E2F1-DP and Myb-MuvB is important to repress mitosis and coordinate the endocycle transcription
Title: Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells.
dDP is required for normal cell proliferation, for optimal DNA synthesis, and for efficient G2/M progression.
Title: dDP is needed for normal cell proliferation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal/ventral axis specification, ovarian follicular epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eggshell chorion gene amplification	TAS Traceable Author Statement more info	PubMed
involved_in endomitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nurse cell apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nurse cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Myb complex	IDA Inferred from Direct Assay more info	PubMed
part_of Rb-E2F complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DP transcription factor

Names: CG4654-PA; CG4654-PB; CG4654-PC; Dp-PA; Dp-PB; Dp-PC; dimerization partner; lethal(2)49Fk

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

13222433..13228202

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057691.4 → NP_477039.1 DP transcription factor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477039.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B8A3X4, O17472, O44080, Q24318, Q86PE0, Q8ML56, Q9V6M0

Related

FBpp0086853

Conserved Domains (3) summary

cd14458
Location:248 → 294

DP_DD; coiled coil [structural motif]

pfam02319
Location:167 → 243

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:255 → 388

DP; Transcription factor DP
NM_001274020.1 → NP_001260949.1 DP transcription factor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260949.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KEQ0

Conserved Domains (3) summary

cd14458
Location:220 → 266

DP_DD; coiled coil [structural motif]

pfam02319
Location:139 → 215

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:227 → 360

DP; Transcription factor DP
NM_165974.3 → NP_725267.1 DP transcription factor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725267.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24318

Related

FBpp0086854

Conserved Domains (3) summary

cd14458
Location:244 → 290

DP_DD; coiled coil [structural motif]

pfam02319
Location:163 → 239

E2F_TDP; E2F/DP family winged-helix DNA-binding domain

pfam08781
Location:251 → 384

DP; Transcription factor DP