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    RhoU RhoU [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31945, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RhoUprovided by FlyBase
    Official Full Name
    RhoUprovided by FlyBase
    Primary source
    FLYBASE:FBgn0083940
    Locus tag
    Dmel_CG34104
    See related
    AllianceGenome:FB:FBgn0083940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12094; CG12102; CG34104; Dmel\CG34104
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Predicted to be active in plasma membrane. Is expressed in several structures, including antennal anlage; gut section; head epidermis primordium; mesoderm; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RhoU in Genome Data Viewer
    Location:
    9B1-9B2; 1-31 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10086527..10148876)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9980560..10042909)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene ZAP3 Neighboring gene uncharacterized protein Neighboring gene NAD(P)HX epimerase Neighboring gene antisense RNA:CR44894 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stripy Ftz target genes are coordinately regulated by Ftz-F1. Hou HY, et al. Dev Biol, 2009 Nov 15. PMID 19679121, Free PMC Article
    2. Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Neisch AL, et al. Mol Biol Cell, 2013 May. PMID 23468526, Free PMC Article
    3. Genome-wide analysis reveals MOF as a key regulator of dosage compensation and gene expression in Drosophila. Kind J, et al. Cell, 2008 May 30. PMID 18510926
    4. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
    5. Transposable element dynamics and PIWI regulation impacts lncRNA and gene expression diversity in Drosophila ovarian cell cultures. Sytnikova YA, et al. Genome Res, 2014 Dec. PMID 25267525, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: 10095218-10101092 mobile_element_type = transposon:297{}93
    • Loc: 10138270-10145710 mobile_element_type = transposon:412{}95

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Cdc42 protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RhoU
    Names
    CG34104-PA
    CG34104-PB
    CG34104-PC
    RhoU-PA
    RhoU-PB
    RhoU-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10086527..10148876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042801.2 → NP_001036266.1  RhoU, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036266.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHU4
      Conserved Domains (2) summary
      cd04130
      Location:393 → 562
      Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42
      smart00174
      Location:395 → 559
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

    2. NM_001298144.1 → NP_001285073.1  RhoU, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285073.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHU4
      Conserved Domains (2) summary
      cd04130
      Location:393 → 562
      Wrch_1; Wnt-1 responsive Cdc42 homolog (Wrch-1) is a Rho family GTPase similar to Cdc42
      smart00174
      Location:395 → 559
      RHO; Rho (Ras homology) subfamily of Ras-like small GTPases

    3. NM_001042802.2 → NP_001036267.1  RhoU, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SXY7, Q9W2Y2
      Conserved Domains (1) summary
      cl21455
      Location:393 → 431
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHU4 Q0KHU4
    Q8SXY7 Q8SXY7

    Gene LinkOut

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