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    Ehbp1 Eps15 homology domain containing protein-binding protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ehbp1provided by FlyBase
    Official Full Name
    Eps15 homology domain containing protein-binding protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034180
    Locus tag
    Dmel_CG15609
    See related
    AllianceGenome:FB:FBgn0034180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    2R11; CG15609; dEHBP-1; dEHBP1; Dmel\CG15609; ehbp1; EHBP1
    Summary
    Involved in several processes, including positive regulation of Notch signaling pathway; secretion by cell; and sensory organ precursor cell division. Located in cell cortex and plasma membrane. Is expressed in adult head and spermatozoon. Orthologous to several human genes including EHBP1 (EH domain binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ehbp1 in Genome Data Viewer
    Location:
    53E4-53E4; 2-81 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17007674..17015894, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12895179..12903399, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Asparaginyl-tRNA synthetase, mitochondrial Neighboring gene Nuclear inhibitor of Protein phosphatase 1 Neighboring gene uncharacterized protein Neighboring gene Poly(A) binding protein interacting protein 1 Neighboring gene Death-associated APAF1-related killer Neighboring gene antisense RNA:CR44390

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Constriction imposed by basement membrane regulates developmental cell migration. Molina López E, et al. PLoS Biol, 2023 Jun. PMID 37379333, Free PMC Article
    2. Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition. Giagtzoglou N, et al. J Cell Sci, 2013 Aug 15. PMID 23788431, Free PMC Article
    3. Cofilin regulator 14-3-3zeta is an evolutionarily conserved protein required for phagocytosis and microbial resistance. Ulvila J, et al. J Leukoc Biol, 2011 May. PMID 21208897
    4. Rab10-Mediated Secretion Synergizes with Tissue Movement to Build a Polarized Basement Membrane Architecture for Organ Morphogenesis. Isabella AJ, et al. Dev Cell, 2016 Jul 11. PMID 27404358, Free PMC Article
    5. B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster. Vrailas-Mortimer AD, et al. MicroPubl Biol, 2021 Jan 18. PMID 33474526, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in basement membrane constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basolateral protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory organ precursor cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Eps15 homology domain containing protein-binding protein 1
    Names
    CG15609-PB
    CG15609-PF
    CG15609-PG
    CG15609-PI
    Ehbp1-PB
    Ehbp1-PF
    Ehbp1-PG
    Ehbp1-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17007674..17015894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144211.2 → NP_001137683.2  Eps15 homology domain containing protein-binding protein 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137683.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZI1, Q8MR93
      Conserved Domains (3) summary
      cd00014
      Location:460 → 562
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:835 → 975
      DUF3585; Protein of unknown function (DUF3585)

    2. NM_206144.2 → NP_995866.1  Eps15 homology domain containing protein-binding protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZL2, Q8MR93
      Conserved Domains (3) summary
      cd00014
      Location:460 → 562
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:828 → 968
      DUF3585; Protein of unknown function (DUF3585)

    3. NM_137335.4 → NP_611179.3  Eps15 homology domain containing protein-binding protein 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611179.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAN2, Q8MR93
      Conserved Domains (3) summary
      cd00014
      Location:438 → 540
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:806 → 946
      DUF3585; Protein of unknown function (DUF3585)

    4. NM_206143.3 → NP_995865.2  Eps15 homology domain containing protein-binding protein 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995865.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZL3, Q8MR93
      Conserved Domains (3) summary
      cd00014
      Location:460 → 562
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam10358
      Location:12 → 165
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:1027 → 1122
      DUF3585; Protein of unknown function (DUF3585)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAN2 A1ZAN2
    A4UZL2 A4UZL2
    A4UZL3 A4UZL3
    B7YZI1 B7YZI1
    Q8MR93 Q8MR93

    Gene LinkOut

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