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    SmD3 Small ribonucleoprotein particle protein SmD3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SmD3provided by FlyBase
    Official Full Name
    Small ribonucleoprotein particle protein SmD3provided by FlyBase
    Primary source
    FLYBASE:FBgn0023167
    Locus tag
    Dmel_CG8427
    See related
    AllianceGenome:FB:FBgn0023167
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8427; dD3; Dmel\CG8427; guf; guf2; l(2)131/7; l(2)154/1; l(2)90/37; Sm D3; smd3; smD3; snRNP Sm D3; SYM10
    Summary
    Predicted to enable RNA binding activity. Involved in several processes, including lymph gland development; nervous system development; and pole plasm oskar mRNA localization. Located in pole plasm. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult brain cell body rind and organism. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human SNRPD3 (small nuclear ribonucleoprotein D3 polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SmD3 in Genome Data Viewer
    Location:
    48E4-48E4; 2-66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12168731..12170003)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8056236..8057508)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ornithine decarboxylase antizyme Neighboring gene antisense RNA:CR46194 Neighboring gene mir-281-2 stem loop Neighboring gene mir-281-1 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila gene for antizyme requires ribosomal frameshifting for expression and contains an intronic gene for snRNP Sm D3 on the opposite strand. Ivanov IP, et al. Mol Cell Biol, 1998 Mar. PMID 9488472, Free PMC Article
    2. P elements inserted in the vicinity of or within the Drosophila snRNP SmD3 gene nested in the first intron of the Ornithine Decarboxylase Antizyme gene affect only the expression of SmD3. Schenkel H, et al. Genetics, 2002 Jun. PMID 12072471, Free PMC Article
    3. Independent transcription of miR-281 in the intron of ODA in Drosophila melanogaster. Xiong H, et al. Biochem Biophys Res Commun, 2009 Jan 23. PMID 19073139
    4. Ecd promotes U5 snRNP maturation and Prp8 stability. Erkelenz S, et al. Nucleic Acids Res, 2021 Feb 22. PMID 33444449, Free PMC Article
    5. Arginine methylation of SmB is required for Drosophila germ cell development. Anne J. Development, 2010 Sep 1. PMID 20659974

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SmD3 was observed to regulate spliceosome and ribosome subunit expression levels and controlled spliceosome and ribosome function via RpL18.
      Title: Small ribonucleoprotein particle protein SmD3 governs the homeostasis of germline stem cells and the crosstalk between the spliceosome and ribosome signals in Drosophila.
    2. study shows that a series of P inserts located within the 5'-untranslated region (5'-UTR) of SmD3 or its promoter affects only the expression of SmD3
      Title: P elements inserted in the vicinity of or within the Drosophila snRNP SmD3 gene nested in the first intron of the Ornithine Decarboxylase Antizyme gene affect only the expression of SmD3.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole plasm oskar mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal snRNP assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SMN-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of commitment complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in pole plasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small nuclear ribonucleoprotein complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small ribonucleoprotein particle protein SmD3
    Names
    CG8427-PA
    SmD3-PA
    gut feeling
    gutfeeling
    small ribonucleoprotein Sm D3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12168731..12170003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165866.3 → NP_725106.1  small ribonucleoprotein particle protein SmD3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725106.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44437
      UniProtKB/TrEMBL
      A0A1B2AJH4
      Related
      FBpp0087094
      Conserved Domains (1) summary
      cd01721
      Location:6 → 75
      Sm_D3; Sm protein D3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44437.1 O44437

    Gene LinkOut

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