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    Qsox1 Quiescin sulfhydryl oxidase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36464, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Qsox1provided by FlyBase
    Official Full Name
    Quiescin sulfhydryl oxidase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0033814
    Locus tag
    Dmel_CG4670
    See related
    AllianceGenome:FB:FBgn0033814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4670; Dmel\CG4670; DmQSOX1; lincRNA.300; qsox1; QSOX1
    Summary
    Predicted to enable flavin-dependent sulfhydryl oxidase activity and protein disulfide isomerase activity. Involved in protein folding in endoplasmic reticulum. Is active in Golgi apparatus and extracellular space. Is expressed in several structures, including adult head; embryonic anal pad; embryonic large intestine; epithelium; and gut section. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1) and QSOX2 (quiescin sulfhydryl oxidase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Qsox1 in Genome Data Viewer
    Location:
    49F11-49F11; 2-68 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13231758..13235296, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9119263..9122801, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Peroxin 13 Neighboring gene fates-shifted Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic Mapping and Phenotypic Analysis of GstE14 (E.4.1) on Eye and Antennae Development in Drosophila melanogaster. Thomson L, et al. MicroPubl Biol, 2024. PMID 38681673, Free PMC Article
    2. Sulfhydryl oxidases: emerging catalysts of protein disulfide bond formation in eukaryotes. Thorpe C, et al. Arch Biochem Biophys, 2002 Sep 1. PMID 12176051
    3. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. Valoskova K, et al. Elife, 2019 Mar 26. PMID 30910009, Free PMC Article
    4. Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. Tien AC, et al. J Cell Biol, 2008 Sep 22. PMID 18809725, Free PMC Article
    5. Pri peptides are mediators of ecdysone for the temporal control of development. Chanut-Delalande H, et al. Nat Cell Biol, 2014 Nov. PMID 25344753

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c13232823-13232743 mobile_element_type = transposon:INE-1{}5012

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin-dependent sulfhydryl oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding in endoplasmic reticulum IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    quiescin sulfhydryl oxidase 1
    Names
    CG4670-PA
    CG4670-PB
    Qsox1-PA
    Qsox1-PB
    NP_001286383.1
    NP_610852.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13231758..13235296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299454.1 → NP_001286383.1  quiescin sulfhydryl oxidase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286383.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQR3
      Conserved Domains (2) summary
      cd02992
      Location:49 → 162
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:430 → 521
      Evr1_Alr; Erv1 / Alr family

    2. NM_137008.3 → NP_610852.1  quiescin sulfhydryl oxidase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610852.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JQR3
      Related
      FBpp0086873
      Conserved Domains (2) summary
      cd02992
      Location:49 → 162
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:430 → 521
      Evr1_Alr; Erv1 / Alr family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQR3 Q7JQR3

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