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    bur burgundy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    burprovided by FlyBase
    Official Full Name
    burgundyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000239
    Locus tag
    Dmel_CG9242
    See related
    AllianceGenome:FB:FBgn0000239
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.193; anon-WO0118547.204; Bur; CG9242; Dmel\CG9242; ES2-2; Gmps; GMPS; gua2; l(2)10523; P174
    Summary
    Enables deubiquitinase activator activity. Involved in axon guidance; positive regulation of heterochromatin formation; and positive regulation of smoothened signaling pathway. Located in polytene chromosome. Part of protein-containing complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bur in Genome Data Viewer
    Location:
    39A7-39B1; 2-54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21174182..21179683, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21174182..21179683, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mitochondrial aconitase 1 Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44911 Neighboring gene Minichromosome maintenance 10 Neighboring gene Ret oncogene Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons. Hahn M, et al. Proc Natl Acad Sci U S A, 2001 Jan 30. PMID 11158593, Free PMC Article
    2. Three purine auxotrophic loci on the second chromosome of Drosophila melanogaster. Johnstone ME, et al. Biochem Genet, 1985 Aug. PMID 2864915
    3. Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention. Takakura M, et al. Proc Natl Acad Sci U S A, 2023 Sep 5. PMID 37639608, Free PMC Article
    4. Nucleotide biosynthetic enzyme GMP synthase is a TRIM21-controlled relay of p53 stabilization. Reddy BA, et al. Mol Cell, 2014 Feb 6. PMID 24462112
    5. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7. van der Knaap JA, et al. Mol Cell, 2005 Mar 4. PMID 15749019

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genetic and gene expression analyses suggested that GMPS/USP7 acts as a transcriptional corepressor
      Title: Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes.
    2. Specifically required in R cells of the retina for the guidance of R-cell axons in the fly visual system.
      Title: De novo GMP synthesis is required for axon guidance in Drosophila.
    3. GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
      Title: GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP synthase (glutamine-hydrolyzing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GMP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GMP synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deubiquitinase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    burgundy
    Names
    CG9242-PB
    CG9242-PC
    GMP synthetase
    GMP-synthetase
    bur-PB
    bur-PC
    enhancer of GMR-sina 2-2
    NP_001286120.1
    NP_620114.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21174182..21179683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299191.1 → NP_001286120.1  burgundy, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286120.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSU9, Q8WSN4, Q9VIE7
      Conserved Domains (3) summary
      cd01742
      Location:19 → 199
      GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
      PRK00074
      Location:16 → 683
      guaA; GMP synthase; Reviewed
      cd01997
      Location:230 → 682
      GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...

    2. NM_138759.4 → NP_620114.3  burgundy, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_620114.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSU9, Q8WSN4, Q9VIE7
      Conserved Domains (3) summary
      cd01742
      Location:19 → 199
      GATase1_GMP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase
      PRK00074
      Location:16 → 683
      guaA; GMP synthase; Reviewed
      cd01997
      Location:230 → 682
      GMP_synthase_C; The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WSN4 Q8WSN4
    Q9VIE7 Q9VIE7

    Gene LinkOut

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