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    to takeout [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43036, updated on 9-Dec-2024

    Summary

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    Official Symbol
    toprovided by FlyBase
    Official Full Name
    takeoutprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039298
    Locus tag
    Dmel_CG11853
    See related
    AllianceGenome:FB:FBgn0039298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11853; CT33074; Dmel\CG11853; JHBP9; Takeout; To
    Summary
    Involved in several processes, including adult feeding behavior; behavioral response to starvation; and male courtship behavior. Located in extracellular space. Is expressed in adult fat body; adult hindgut; adult pericerebral fat mass; and organism subdivision. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    96C7-96C7; 3-87 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25240180..25241668)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21065902..21067390)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Sil1 nucleotide exchange factor Neighboring gene Juvenile hormone binding protein 7 Neighboring gene uncharacterized protein Neighboring gene bag of marbles Neighboring gene stable intronic sequence RNA CR46364 Neighboring gene Ribosomal protein S27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of feeding behaviour and locomotor activity by takeout in Drosophila. Meunier N, et al. J Exp Biol, 2007 Apr. PMID 17401125
    2. Comparative genomics of insect juvenile hormone biosynthesis. Noriega FG, et al. Insect Biochem Mol Biol, 2006 Apr. PMID 16551550, Free PMC Article
    3. takeout-dependent longevity is associated with altered Juvenile Hormone signaling. Chamseddin KH, et al. Mech Ageing Dev, 2012 Nov-Dec. PMID 22940452, Free PMC Article
    4. Genes encoding putative Takeout/juvenile hormone binding proteins in the honeybee (Apis mellifera) and modulation by age and juvenile hormone of the takeout-like gene GB19811. Hagai T, et al. Insect Biochem Mol Biol, 2007 Jul. PMID 17550825
    5. Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. Antosh M, et al. Cell Cycle, 2011 Mar 15. PMID 21325893, Free PMC Article

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. There are 23 takeout family members in Drosophila melanogaster, and homologues of this family are distributed across insect species. Despite their sequence divergence takeout members from Aedes aegypti and Epiphas postvittana, as well as family members from D. melanogaster can substitute for takeout in courtship, demonstrating their functional conservation.
      Title: High functional conservation of takeout family members in a courtship model system.
    2. takeout-dependent longevity is associated with altered Juvenile Hormone signaling
      Title: takeout-dependent longevity is associated with altered Juvenile Hormone signaling.
    3. We show that a number of genes in the takeout gene family show male-biased expression in D. melanogaster, largely in non-reproductive tissues.
      Title: Diversification of takeout, a male-biased gene family in Drosophila.
    4. Data show that takeout levels are low in flies with reduced Pdp1epsilon and high in flies with increased amounts of Pdp1epsilon.
      Title: The circadian output gene takeout is regulated by Pdp1epsilon.
    5. takeout plays a central role as a feeding regulator and may act by modulating the circulating Juvenile Hormone level.
      Title: Regulation of feeding behaviour and locomotor activity by takeout in Drosophila.
    6. Drosophila Takeout gene expression varied with diurnal or circadian rhythms. These findings suggest that Apis mellifera GB19811 is not an ortholog of Takeout.
      Title: Genes encoding putative Takeout/juvenile hormone binding proteins in the honeybee (Apis mellifera) and modulation by age and juvenile hormone of the takeout-like gene GB19811.
    7. A loss-of-function mutation in the takeout gene reduces male courtship and synergizes with fruitless mutations, suggesting that takeout plays a redundant role with other fru-dependent factors involved in male mating behavior
      Title: The Drosophila takeout gene is regulated by the somatic sex-determination pathway and affects male courtship behavior.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in adult feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in circadian rhythm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in circadian rhythm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in feeding behavior NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in feeding behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in male courtship behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in male courtship behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in multicellular organismal reproductive process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to starvation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in rhythmic behavior TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    takeout
    Names
    CG11853-PA
    CG11853-PB
    juvenile hormone binding protein 9
    take-out
    takeou
    to-PA
    to-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25240180..25241668
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300596.1 → NP_001287525.1  takeout, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287525.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MR66, Q9VBV2, Q9VBV3
      UniProtKB/TrEMBL
      A0A0B4LHM9
      Conserved Domains (1) summary
      pfam06585
      Location:5 → 245
      JHBP; Haemolymph juvenile hormone binding protein (JHBP)

    2. NM_079773.2 → NP_524497.1  takeout, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524497.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MR66, Q9VBV2, Q9VBV3
      UniProtKB/TrEMBL
      A0A0B4LHM9
      Related
      FBpp0084185, FBtr0084810
      Conserved Domains (1) summary
      pfam06585
      Location:5 → 245
      JHBP; Haemolymph juvenile hormone binding protein (JHBP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHM9 A0A0B4LHM9
    Q9VBV3.1 Q9VBV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
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