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    CG6659 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32854, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG6659provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030946
    Locus tag
    Dmel_CG6659
    See related
    AllianceGenome:FB:FBgn0030946
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG6659
    Summary
    Predicted to enable mannosyltransferase activity. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in spermatogenic failure 9. Orthologous to several human genes including DPY19L1 (dpy-19 like C-mannosyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG6659 in Genome Data Viewer
    Location:
    17C7-17D1; 1-60 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18653392..18657286, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18547425..18551319, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 35kDa Neighboring gene Houki Neighboring gene Inhibitor of growth family, member 3 Neighboring gene fused Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45514

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stress. Dalton HM, et al. PLoS Genet, 2022 Sep. PMID 36166480, Free PMC Article
    2. An anti-inflammatory transcriptional cascade conserved from flies to humans. Pavlidaki A, et al. Cell Rep, 2022 Oct 18. PMID 36261018
    3. A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Guichard A, et al. Cell Rep, 2023 Aug 29. PMID 37480566, Free PMC Article
    4. Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates. Olson JM, et al. G3 (Bethesda), 2019 Nov 5. PMID 31690598, Free PMC Article
    5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6659-PA
    CG6659-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18653392..18657286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133089.2 → NP_573317.1  uncharacterized protein Dmel_CG6659, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573317.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KUV6, Q9VWR8, Q9VWR9
      Related
      FBpp0074383, FBtr0074612
      Conserved Domains (2) summary
      pfam06614
      Location:521 → 599
      Neuromodulin; Neuromodulin
      pfam10034
      Location:18 → 852
      Dpy19; Q-cell neuroblast polarization

    2. NM_167627.1 → NP_728189.1  uncharacterized protein Dmel_CG6659, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728189.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VWR8
      Related
      FBpp0074384, FBtr0074613
      Conserved Domains (1) summary
      pfam10034
      Location:1 → 737
      Dpy19; Q-cell neuroblast polarization
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWR8.1 Q9VWR8

    Gene LinkOut

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