Actn alpha actinin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Actnprovided by FlyBase
Official Full Name: alpha actininprovided by FlyBase
Primary source: FLYBASE:FBgn0000667
Locus tag: Dmel_CG4376
See related: AllianceGenome:FB:FBgn0000667
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: actn; ACTN; alpha-actinin; alphaActn; CG4376; CT14163; CT14232; Dmel\CG4376; EG:133E12.1; fliA; GA17; HM-29; l(1)2Cb; l(1)EA82; y
Summary: Enables actin filament binding activity. Involved in actin filament bundle assembly and sarcomere organization. Located in Z disc. Is expressed in several structures, including adult head; adult heart; ganglia; mesoderm; and muscle cell. Used to study focal segmental glomerulosclerosis 1. Human ortholog(s) of this gene implicated in congenital myopathy 8; focal segmental glomerulosclerosis (multiple); intrinsic cardiomyopathy (multiple); and platelet-type bleeding disorder 15. Orthologous to several human genes including ACTN1 (actinin alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 2C4-2C7; 1-0.5 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (2023822..2042311, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (1917855..1936344, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Flight assays also show that a Zasp52 mutant suppresses the a-actinin mutant phenotype, indicating that both proteins are core structural Z-disc proteins required for optimal Z-disc function.
Title: Zasp52, a Core Z-disc Protein in Drosophila Indirect Flight Muscles, Interacts with α-Actinin via an Extended PDZ Domain.
alpha-actinin is involved in the organisation of the cytoskeleton in a non-muscle tissue in Drosophila
Title: Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1845 (e-PCR)
- UniSTS:67470

Dm1871 (e-PCR)
- UniSTS:70290

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament bundle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell development	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcomere organization	IDA Inferred from Direct Assay more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cortical actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha actinin

Names: Actn-PA; Actn-PB; Actn-PC; Actn-PD; Actn-PF; Actn-PG; Actn-PH; Actn-PI; Actn-PJ; Alpha-actinin; CG4376-PA; CG4376-PB; CG4376-PC; CG4376-PD; CG4376-PF; CG4376-PG; CG4376-PH; CG4376-PI; CG4376-PJ; a-actinin; actinin; flightless A; flightless-A; lethal(1)2cb

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

2023822..2042311 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058137.6 → NP_477485.1 alpha actinin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477485.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGA7

Related

FBpp0070331

Conserved Domains (5) summary

cd00051
Location:775 → 842

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:420 → 647

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:847 → 913

EFhand_Ca_insen; Ca2+ insensitive EF hand

cd21214
Location:31 → 135

CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family

cd21216
Location:139 → 252

CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
NM_001272235.1 → NP_001259164.1 alpha actinin, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259164.1

Status: REVIEWED

UniProtKB/TrEMBL

F0JAG6

Conserved Domains (5) summary

cd00051
Location:755 → 822

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:398 → 627

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:827 → 893

EFhand_Ca_insen; Ca2+ insensitive EF hand

cd21214
Location:31 → 135

CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family

cd21216
Location:139 → 253

CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
NM_058136.4 → NP_477484.2 alpha actinin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477484.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P18091

Related

FBpp0070330

Conserved Domains (5) summary

cd00051
Location:753 → 820

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:398 → 625

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:825 → 891

EFhand_Ca_insen; Ca2+ insensitive EF hand

cd21214
Location:31 → 135

CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family

cd21216
Location:139 → 253

CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
NM_166920.2 → NP_726784.1 alpha actinin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726784.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MS06

Related

FBpp0070329

Conserved Domains (5) summary

cd00051
Location:753 → 820

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:398 → 625

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:825 → 891

EFhand_Ca_insen; Ca2+ insensitive EF hand

cd21214
Location:31 → 135

CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family

cd21216
Location:139 → 252

CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
NM_001272237.1 → NP_001259166.1 alpha actinin, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259166.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGA7

Conserved Domains (5) summary

cd00051
Location:775 → 842

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:420 → 647

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:847 → 913

EFhand_Ca_insen; Ca2+ insensitive EF hand

cd21214
Location:31 → 135

CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family

cd21216
Location:139 → 252

CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
NM_001272238.1 → NP_001259167.1 alpha actinin, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259167.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGA7

Conserved Domains (5) summary

cd00051
Location:775 → 842

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:420 → 647

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:847 → 913

EFhand_Ca_insen; Ca2+ insensitive EF hand

cd21214
Location:31 → 135

CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family

cd21216
Location:139 → 252

CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
NM_001272236.1 → NP_001259165.1 alpha actinin, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259165.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PGA7

Conserved Domains (5) summary

cd00051
Location:775 → 842

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:420 → 647

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:847 → 913

EFhand_Ca_insen; Ca2+ insensitive EF hand

cd21214
Location:31 → 135

CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family

cd21216
Location:139 → 252

CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
NM_001201603.2 → NP_001188532.1 alpha actinin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188532.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MS06

Conserved Domains (5) summary

cd00051
Location:753 → 820

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:398 → 625

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:825 → 891

EFhand_Ca_insen; Ca2+ insensitive EF hand

cd21214
Location:31 → 135

CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family

cd21216
Location:139 → 252

CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
NM_001201604.2 → NP_001188533.1 alpha actinin, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188533.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MS06

Conserved Domains (5) summary

cd00051
Location:753 → 820

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd00176
Location:398 → 625

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam08726
Location:825 → 891

EFhand_Ca_insen; Ca2+ insensitive EF hand

cd21214
Location:31 → 135

CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family

cd21216
Location:139 → 252

CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family