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    Ing3 Inhibitor of growth family, member 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32853, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ing3provided by FlyBase
    Official Full Name
    Inhibitor of growth family, member 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0030945
    Locus tag
    Dmel_CG6632
    See related
    AllianceGenome:FB:FBgn0030945
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6632; dIng3; dIng3~; Dmel\CG6632; ING3
    Summary
    Predicted to enable methylated histone binding activity. Involved in DNA repair-dependent chromatin remodeling. Located in nucleus. Part of NuA4 histone acetyltransferase complex. Orthologous to human ING3 (inhibitor of growth family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ing3 in Genome Data Viewer
    Location:
    17C7-17C7; 1-60 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18650718..18653091, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18544751..18547124, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Rab11 interacting protein Neighboring gene Nucleoporin 35kDa Neighboring gene Houki Neighboring gene uncharacterized protein Neighboring gene fused Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. Kanda H, et al. J Biol Chem, 2002 Aug 9. PMID 12084706
    2. Ras-ERK-ETS inhibition alleviates neuronal mitochondrial dysfunction by reprogramming mitochondrial retrograde signaling. Duncan OF, et al. PLoS Genet, 2018 Jul. PMID 30059502, Free PMC Article
    3. Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression. Kusch T, et al. Proc Natl Acad Sci U S A, 2014 Apr 1. PMID 24639513, Free PMC Article
    4. In and out: histone variant exchange in chromatin. Jin J, et al. Trends Biochem Sci, 2005 Dec. PMID 16257529
    5. Enhancer of Polycomb and the Tip60 complex repress hematological tumor initiation by negatively regulating JAK/STAT pathway activity. Bailetti AA, et al. Dis Model Mech, 2019 May 30. PMID 31072879, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in DNA repair-dependent chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inhibitor of growth family, member 3
    Names
    CG6632-PA
    Ing3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18650718..18653091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133088.1 → NP_573316.1  inhibitor of growth family, member 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573316.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWS0
      Related
      FBpp0074385, FBtr0074614
      Conserved Domains (2) summary
      cd15585
      Location:630 → 674
      PHD_ING3; PHD finger found in inhibitor of growth protein 3 (ING3) and similar proteins
      pfam12998
      Location:3 → 103
      ING; Inhibitor of growth proteins N-terminal histone-binding
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MR26 Q8MR26
    Q9VWS0 Q9VWS0

    Gene LinkOut

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