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    PolQ DNA polymerase theta [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PolQprovided by FlyBase
    Official Full Name
    DNA polymerase thetaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0002905
    Locus tag
    Dmel_CG6019
    See related
    AllianceGenome:FB:FBgn0002905
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0443/09; AAF54858; CG6019; Dmel\CG6019; DNApol-theta; mus-308; mus308; Mus308; Nuc3; Pol theta; polq; POLQ
    Summary
    Enables DNA-directed DNA polymerase activity. Involved in DNA metabolic process. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; embryonic/larval midgut primordium; and mesoderm. Orthologous to human POLQ (DNA polymerase theta). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PolQ in Genome Data Viewer
    Location:
    87C6-87C6; 3-52 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12705523..12712299, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8531245..8538021, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Actin-related protein 1 Neighboring gene uncharacterized protein Neighboring gene Ninjurin C Neighboring gene Putative Achaete Scute Target 1 Neighboring gene uncharacterized protein Neighboring gene Malic enzyme Neighboring gene long non-coding RNA:CR44231

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mitochondrial nuclease is modified in Drosophila mutants (mus308) that are hypersensitive to DNA crosslinking agents. Sakaguchi K, et al. Mol Gen Genet, 1990 Dec. PMID 2125112
    2. DNA polymerase POLQ and cellular defense against DNA damage. Yousefzadeh MJ, et al. DNA Repair (Amst), 2013 Jan 1. PMID 23219161, Free PMC Article
    3. The Drosophila mus 308 gene product, implicated in tolerance of DNA interstrand crosslinks, is a nuclear protein found in both ovaries and embryos. Pang M, et al. DNA Repair (Amst), 2005 Aug 15. PMID 15961355
    4. The hypermutability conferred by the mus308 mutation of Drosophila is not specific for cross-linking agents. Aguirrezabalaga I, et al. Mutat Res, 1995 May. PMID 7739612
    5. A possible functional role for a new class of eukaryotic DNA polymerases. Burtis KC, et al. Curr Biol, 1997 Dec 1. PMID 9382854

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation.
      Title: Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation.
    2. Both polymerase and ATPase activities are required during microhomology-mediated end joining and interstrand crosslink repair.
      Title: Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair.
    3. DNA polymerase theta, encoded by the mus308 gene, plays a crucial role in DNA ligase 4-independent alternative end joining.
      Title: Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.
    4. mus 308 gene product localizes throughout nuclei in wild-type cells but appears to be absent in a mus 308 mutant Drosophila
      Title: The Drosophila mus 308 gene product, implicated in tolerance of DNA interstrand crosslinks, is a nuclear protein found in both ovaries and embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 5'-deoxyribose-5-phosphate lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA synthesis involved in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA synthesis involved in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via alternative nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via alternative nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair involved in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase theta
    Names
    CG6019-PA
    Nuclease-3
    PolQ-PA
    mutagen-sensitive 308
    pol theta
    NP_524333.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12705523..12712299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079609.3 → NP_524333.1  DNA polymerase theta [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524333.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18475, Q5BI65
      Related
      FBpp0082131
      Conserved Domains (5) summary
      cd08638
      Location:1668 → 2053
      DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
      smart00490
      Location:542 → 616
      HELICc; helicase superfamily c-terminal domain
      COG0749
      Location:1489 → 2055
      PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
      COG1204
      Location:209 → 978
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      pfam00270
      Location:251 → 404
      DEAD; DEAD/DEAH box helicase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18475.1 O18475

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