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    CG3764 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39902, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3764provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036684
    Locus tag
    Dmel_CG3764
    See related
    AllianceGenome:FB:FBgn0036684
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3764
    Summary
    Predicted to enable ATPase inhibitor activity and protein-folding chaperone binding activity. Predicted to be active in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; antennal primordium; central brain anlage; and head epidermis primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human FNIP1 (folliculin interacting protein 1) and FNIP2 (folliculin interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3764 in Genome Data Viewer
    Location:
    73E2-73E4; 3-45 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16994717..17012565, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16987817..17005665, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 73D Neighboring gene Odorant-binding protein 73a Neighboring gene Oxoglutarate dehydrogenase Neighboring gene Ephexin Neighboring gene mir-2500 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Kadener S, et al. Genes Dev, 2007 Jul 1. PMID 17578907, Free PMC Article
    2. A genetic toolkit for tagging intronic MiMIC containing genes. Nagarkar-Jaiswal S, et al. Elife, 2015 Jun 23. PMID 26102525, Free PMC Article
    3. Mitf is a master regulator of the v-ATPase, forming a control module for cellular homeostasis with v-ATPase and TORC1. Zhang T, et al. J Cell Sci, 2015 Aug 1. PMID 26092939, Free PMC Article
    4. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Ponting CP, et al. Genome Res, 2001 Dec. PMID 11731489
    5. Systems genetics of complex traits in Drosophila melanogaster. Ayroles JF, et al. Nat Genet, 2009 Mar. PMID 19234471, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c16999682-16999637 mobile_element_type = transposon:INE-1{}3912

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3764-PA
    CG3764-PB
    CG3764-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16994717..17012565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275048.1 → NP_001261977.1  uncharacterized protein Dmel_CG3764, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTN7, Q8T0L7
      Conserved Domains (3) summary
      pfam14636
      Location:101 → 222
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:461 → 692
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:1269 → 1460
      FNIP_C; Folliculin-interacting protein C-terminus

    2. NM_001275049.1 → NP_001261978.1  uncharacterized protein Dmel_CG3764, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261978.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0L7, Q9VVC7
      Conserved Domains (3) summary
      pfam14636
      Location:17 → 138
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:377 → 608
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:1185 → 1376
      FNIP_C; Folliculin-interacting protein C-terminus

    3. NM_140686.4 → NP_648943.2  uncharacterized protein Dmel_CG3764, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648943.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0L7, Q9VVC7
      Related
      FBpp0075057
      Conserved Domains (3) summary
      pfam14636
      Location:17 → 138
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:377 → 608
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:1185 → 1376
      FNIP_C; Folliculin-interacting protein C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E3CTN7 E3CTN7
    Q8T0L7 Q8T0L7
    Q9VVC7 Q9VVC7

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