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    Tango5 Transport and Golgi organization 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 326232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tango5provided by FlyBase
    Official Full Name
    Transport and Golgi organization 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0052675
    Locus tag
    Dmel_CG32675
    See related
    AllianceGenome:FB:FBgn0052675
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1534; CG32675; Dmel\CG32675; TANGO5; vmp1
    Summary
    Involved in Golgi organization and protein secretion. Located in endoplasmic reticulum. Is expressed in adult head. Orthologous to human VMP1 (vacuole membrane protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tango5 in Genome Data Viewer
    Location:
    9E4-9E6; 1-32 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10760048..10764413, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10654081..10658446, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene stuxnet Neighboring gene long non-coding RNA:CR44766 Neighboring gene raspberry Neighboring gene Rabphilin Neighboring gene Autophagy-related 8a Neighboring gene BTB (POZ) domain containing 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease. Shen JL, et al. Curr Biol, 2021 Jul 26. PMID 34019822, Free PMC Article
    2. Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability. Dutta D, et al. Proc Natl Acad Sci U S A, 2024 Feb 27. PMID 38381787, Free PMC Article
    3. Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Ambegaokar SS, et al. Hum Mol Genet, 2011 Dec 15. PMID 21949350, Free PMC Article
    4. A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. Kim YI, et al. BMC Cell Biol, 2010 Jan 25. PMID 20100334, Free PMC Article
    5. New components of Drosophila leg development identified through genome wide association studies. Grubbs N, et al. PLoS One, 2013. PMID 23560084, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transport and golgi organization 5
    Names
    CG32675-PA
    CG32675-PB
    CG32675-PC
    CG32675-PD
    CG32675-PE
    CG32675-PF
    Tango5-PA
    Tango5-PB
    Tango5-PC
    Tango5-PD
    Tango5-PE
    Tango5-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10760048..10764413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298157.1 → NP_001285086.1  transport and golgi organization 5, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP43, Q9W2S0, Q9W2S1
      Conserved Domains (1) summary
      cl00429
      Location:346 → 395
      SNARE_assoc; SNARE associated Golgi protein

    2. NM_167244.3 → NP_727446.1  transport and golgi organization 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727446.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVQ7
      Related
      FBpp0071428
      Conserved Domains (1) summary
      cl00429
      Location:244 → 293
      SNARE_assoc; SNARE associated Golgi protein

    3. NM_167242.3 → NP_727444.1  transport and golgi organization 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727444.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP43, Q9W2S0, Q9W2S1
      Related
      FBpp0071429
      Conserved Domains (1) summary
      cl00429
      Location:346 → 395
      SNARE_assoc; SNARE associated Golgi protein

    4. NM_001169245.2 → NP_001162716.1  transport and golgi organization 5, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP43, Q9W2S0, Q9W2S1
      Conserved Domains (1) summary
      cl00429
      Location:346 → 395
      SNARE_assoc; SNARE associated Golgi protein

    5. NM_001272501.1 → NP_001259430.1  transport and golgi organization 5, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259430.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP43, Q9W2S0, Q9W2S1
      Conserved Domains (1) summary
      cl00429
      Location:346 → 395
      SNARE_assoc; SNARE associated Golgi protein

    6. NM_167243.3 → NP_727445.1  transport and golgi organization 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727445.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP43, Q9W2S0, Q9W2S1
      Related
      FBpp0071430
      Conserved Domains (1) summary
      cl00429
      Location:346 → 395
      SNARE_assoc; SNARE associated Golgi protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVQ7 Q7KVQ7
    Q9W2S1 Q9W2S1

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