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    Pa1 PTIP associated 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32079, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pa1provided by FlyBase
    Official Full Name
    PTIP associated 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0287454
    Locus tag
    Dmel_CG11750
    See related
    AllianceGenome:FB:FBgn0287454
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-10B; anon-10Ba; BcDNA:RE09126; BcDNA:RH21749; CG11750; Dmel\CG11750; dPA1; PA1
    Summary
    Part of MLL3/4 complex. Is expressed in organism. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Orthologous to human PAGR1 (PAXIP1 associated glutamate rich protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pa1 in Genome Data Viewer
    Location:
    10B5-10B5; 1-34 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11359236..11360929)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11253269..11254962)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene dishevelled Neighboring gene hopscotch Neighboring gene Tim8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dishevelled is required during wingless signaling to establish both cell polarity and cell identity. Theisen H, et al. Development, 1994 Feb. PMID 8149913
    2. Dissecting the complexity of CNV pathogenicity: insights from Drosophila and zebrafish models. Yusuff T, et al. Curr Opin Genet Dev, 2021 Jun. PMID 33812298, Free PMC Article
    3. Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4. Herz HM, et al. Genes Dev, 2012 Dec 1. PMID 23166019, Free PMC Article
    4. The COMPASS family of H3K4 methylases in Drosophila. Mohan M, et al. Mol Cell Biol, 2011 Nov. PMID 21875999, Free PMC Article
    5. COMPASS and SWI/SNF complexes in development and disease. Cenik BK, et al. Nat Rev Genet, 2021 Jan. PMID 32958894

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PTIP associated 1
    Names
    CG11750-PA
    PTIP-associated 1
    Pa1-PA
    anon-10Ba

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11359236..11360929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132484.4 → NP_572712.1  PTIP associated 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572712.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYZ8
      Related
      FBpp0073312
      Conserved Domains (1) summary
      pfam15364
      Location:18 → 116
      PAXIP1_C; PAXIP1-associated-protein-1 C term PTIP binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VYZ8 Q9VYZ8

    Gene LinkOut

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