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    Sas-6 Spindle assembly abnormal 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sas-6provided by FlyBase
    Official Full Name
    Spindle assembly abnormal 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0039731
    Locus tag
    Dmel_CG15524
    See related
    AllianceGenome:FB:FBgn0039731
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15524; Dmel\CG15524; dsas-6; DSas-6; DSAS-6; Dsas6; DSas6; sas-6; SAS-6; sas6; Sas6; SAS6
    Summary
    Involved in microtubule organizing center organization and protein localization to centrosome. Located in centriole; centrosome; and ciliary basal body. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 14. Orthologous to human SASS6 (SAS-6 centriolar assembly protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sas-6 in Genome Data Viewer
    Location:
    99D1-99D1; 3-100 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29995357..29997034)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25821079..25822756)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Acid phosphatase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly. Wang WJ, et al. Elife, 2015 Nov 26. PMID 26609813, Free PMC Article
    2. The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies. Cottee MA, et al. Elife, 2015 May 23. PMID 26002084, Free PMC Article
    3. Targeting Drosophila Sas6 to mitochondria reveals its high affinity for Gorab. Kovacs L, et al. Biol Open, 2022 Nov 1. PMID 36331102, Free PMC Article
    4. DSAS-6 organizes a tube-like centriole precursor, and its absence suggests modularity in centriole assembly. Rodrigues-Martins A, et al. Curr Biol, 2007 Sep 4. PMID 17689959
    5. Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila. Baumbach J, et al. Biol Open, 2012 Oct 15. PMID 23213376, Free PMC Article

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting Drosophila Sas6 to mitochondria reveals its high affinity for Gorab.
      Title: Targeting Drosophila Sas6 to mitochondria reveals its high affinity for Gorab.
    2. SAPs as a new model to probe the pathway of centriole and centrosome assembly.
      Title: SAPs as a new model to probe the pathway of centriole and centrosome assembly.
    3. The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication.
      Title: The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication.
    4. The Singularity of the Drosophila Male Germ Cell Centriole: The Asymmetric Distribution of Sas4 and Sas6.
      Title: The Singularity of the Drosophila Male Germ Cell Centriole: The Asymmetric Distribution of Sas4 and Sas6.
    5. A molecular mechanism for the procentriole recruitment of Ana2.
      Title: A molecular mechanism for the procentriole recruitment of Ana2.
    6. Sas-6 and Poc1B interact during proximal centriole-like structure formation.
      Title: Poc1B and Sas-6 Function Together during the Atypical Centriole Formation in Drosophila melanogaster.
    7. Data dhow that spindle assembly abnormal 6 protein (SAS-6) is recruited to the centriole through an undescribed pathway mediated by pericentrin.
      Title: Pericentrin-mediated SAS-6 recruitment promotes centriole assembly.
    8. These results indicate that centriole biogenesis does not strictly depend on SAS-6 self-assembly, and may require preexisting centrioles to ensure structural accuracy, fundamentally deviating from the current paradigm.
      Title: De novo centriole formation in human cells is error-prone and does not require SAS-6 self-assembly.
    9. Thus, efficient centriole duplication in flies requires the homo-oligomerisation of both Sas-6 and Ana2.
      Title: The homo-oligomerisation of both Sas-6 and Ana2 is required for efficient centriole assembly in flies.
    10. DSas-6 and Ana2 normally cooperate to drive the formation of the centriole inner cartwheel and they promote both centriole duplication and centriole cohesion in a Sak/Plk4-dependent manner.
      Title: DSas-6 and Ana2 coassemble into tubules to promote centriole duplication and engagement.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in centriole assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centriole replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in centriole replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centriole-centriole cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in centrosome cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centrosome duplication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ciliary basal body organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ciliary basal body organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    spindle assembly abnormal 6
    Names
    CG15524-PA
    Sas-6-PA
    spindle assembly abnormal 6 ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29995357..29997034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143499.3 → NP_651756.1  spindle assembly abnormal 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651756.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T8U6, Q9VAC8, S0ASJ5
      Related
      FBpp0084912
      Conserved Domains (1) summary
      pfam16531
      Location:59 → 152
      SAS-6_N; Centriolar protein SAS N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAC8.2 Q9VAC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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