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    Phf5a PHD finger protein 5a [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33909, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phf5aprovided by FlyBase
    Official Full Name
    PHD finger protein 5aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031822
    Locus tag
    Dmel_CG9548
    See related
    AllianceGenome:FB:FBgn0031822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RH02789; CG9548; Dmel\CG9548; PHF5A
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human PHF5A (PHD finger protein 5A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Phf5a in Genome Data Viewer
    Location:
    26D9-26D9; 2-20 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6490155..6490843, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6490155..6490843, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45463 Neighboring gene Daxx-like protein Neighboring gene Kynurenine formamidase Neighboring gene Coat Protein (coatomer) epsilon Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs. Laver JD, et al. Cell Rep, 2020 Mar 10. PMID 32160542
    2. Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms. Saha N, et al. BMC Genomics, 2016 Feb 13. PMID 26872827, Free PMC Article
    3. The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing. Stegeman R, et al. J Mol Biol, 2016 Sep 11. PMID 27185460, Free PMC Article
    4. The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting. Liang D, et al. Mol Cell, 2017 Dec 7. PMID 29174924, Free PMC Article
    5. Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. Mack PD, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798875, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    PHD finger protein 5a
    Names
    CG9548-PA
    Phf5a-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6490155..6490843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135194.3 → NP_609038.1  PHD finger protein 5a [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609038.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B5RIJ7, Q8MQM8, Q9VMC8
      UniProtKB/TrEMBL
      A0A1B2AJZ5
      Related
      FBpp0078894
      Conserved Domains (1) summary
      pfam03660
      Location:1 → 104
      PHF5; PHF5-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMC8.2 Q9VMC8

    Gene LinkOut

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    Chemical Information
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