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    Ssdp Sequence-specific single-stranded DNA-binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42177, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ssdpprovided by FlyBase
    Official Full Name
    Sequence-specific single-stranded DNA-binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011481
    Locus tag
    Dmel_CG7187
    See related
    AllianceGenome:FB:FBgn0011481
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7187; Dmel\CG7187; l(3)neo48; ssdp
    Summary
    Enables sequence-specific single stranded DNA binding activity. Involved in embryonic pattern specification; positive regulation of canonical Wnt signaling pathway; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; ganglia; and mesoderm. Used to study autism spectrum disorder. Orthologous to several human genes including SSBP2 (single stranded DNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ssdp in Genome Data Viewer
    Location:
    90F6-90F7; 3-62 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18192494..18199595, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14018216..14025317, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Actin-related protein 5 Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 17 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster. Salim S, et al. PLoS Biol, 2023 Jul. PMID 37486945, Free PMC Article
    2. Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo. van Meyel DJ, et al. Development, 2003 May. PMID 12642495
    3. Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. Chen L, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12381786, Free PMC Article
    4. The pronotum LIM-HD gene tailup is both a positive and a negative regulator of the proneural genes achaete and scute of Drosophila. de Navascués J, et al. Mech Dev, 2010 Sep-Dec. PMID 20580820
    5. The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3. Gajan A, et al. Epigenetics Chromatin, 2016. PMID 26848313, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster.
      Title: The ortholog of human ssDNA-binding protein SSBP3 influences neurodevelopment and autism-like behaviors in Drosophila melanogaster.
    2. The authors use a proteomics approach to discover the Chip/LDB-SSDP (ChiLS) complex as the ligand specifically binding to NPF motif of Pygo proteins.
      Title: An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c18196895-18196700 mobile_element_type = transposon:HMS-Beagle{}4853

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sequence-specific single stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sequence-specific single-stranded DNA-binding protein
    Names
    CG7187-PA
    CG7187-PB
    CG7187-PC
    CG7187-PD
    Sequence-specific single-strand DNA-binding protein
    Ssdp-PA
    Ssdp-PB
    Ssdp-PC
    Ssdp-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18192494..18199595 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169794.2 → NP_732304.1  Sequence-specific single-stranded DNA-binding protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732304.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ9, Q8MZ49, Q9VEB9
      Related
      FBpp0083032
      Conserved Domains (1) summary
      pfam04503
      Location:81 → 393
      SSDP; Single-stranded DNA binding protein, SSDP

    2. NM_001275769.1 → NP_001262698.1  Sequence-specific single-stranded DNA-binding protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGW6, C8VUZ9, Q8MZ49
      Conserved Domains (1) summary
      pfam04503
      Location:81 → 393
      SSDP; Single-stranded DNA binding protein, SSDP

    3. NM_169795.1 → NP_732305.1  Sequence-specific single-stranded DNA-binding protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ9, Q8MZ49, Q9VEB9
      Related
      FBpp0083033, FBtr0083613
      Conserved Domains (1) summary
      pfam04503
      Location:81 → 393
      SSDP; Single-stranded DNA binding protein, SSDP

    4. NM_142431.1 → NP_650688.1  Sequence-specific single-stranded DNA-binding protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650688.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ9, Q8MZ49, Q9VEB9
      Related
      FBpp0083031, FBtr0083611
      Conserved Domains (1) summary
      pfam04503
      Location:81 → 393
      SSDP; Single-stranded DNA binding protein, SSDP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGW6 A0A0B4KGW6
    Q8MZ49 Q8MZ49
    Q9VEB9 Q9VEB9

    Gene LinkOut

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