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    Pgcl Pepsinogen C-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 30984, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgclprovided by FlyBase
    Official Full Name
    Pepsinogen C-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011822
    Locus tag
    Dmel_CG13374
    See related
    AllianceGenome:FB:FBgn0011822
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13374; Dmel\CG13374; EG:EG0001.1; pcl; PCL; scbeta; T2
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Involved in establishment of imaginal disc-derived wing hair orientation. Predicted to be active in lysosome. Orthologous to several human genes including PGA3 (pepsinogen A3) and PGA5 (pepsinogen A5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pgcl in Genome Data Viewer
    Location:
    1B2-1B2; 1-0 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (436139..437448, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (330172..331481, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene scute Neighboring gene lethal of scute Neighboring gene Cytochrome P450 4g1 Neighboring gene asense

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A unitary basis for different Hairy-wing mutations of Drosophila melanogaster. Balcells L, et al. EMBO J, 1988 Dec 1. PMID 3145198, Free PMC Article
    2. In vivo construction of transgenes in Drosophila. Takeuchi H, et al. Genetics, 2007 Apr. PMID 17179096, Free PMC Article
    3. Molecular genetics of the achaete-scute gene complex of D. melanogaster. Campuzano S, et al. Cell, 1985 Feb. PMID 3917860
    4. Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete-scute complex are associated with variation in bristle number in Drosophila melanogaster. Long AD, et al. Genetics, 2000 Mar. PMID 10757767, Free PMC Article
    5. Molecular nature of the Drosophila sex determination signal and its link to neurogenesis. Erickson JW, et al. Science, 1991 Mar 1. PMID 1900130

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our results raise the possibility that Pcl regulates Wg expression post-transcriptionally, and PCP, by proteolytic cleavages.
      Title: A novel planar polarity gene pepsinogen-like regulates wingless expression in a posttranscriptional manner.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of imaginal disc-derived wing hair orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pepsinogen C-like
    Names
    CG13374-PA
    Pgcl-PA
    pepsinogen-like
    scute beta
    NP_525030.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      436139..437448 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080291.4 → NP_525030.1  pepsinogen C-like [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525030.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76921, Q9W5G3
      Related
      FBpp0070095
      Conserved Domains (2) summary
      pfam00026
      Location:76 → 379
      Asp; Eukaryotic aspartyl protease
      cl11403
      Location:67 → 378
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76921 O76921
    Q5BIE7 Q5BIE7
    Q9W5G3 Q9W5G3

    Gene LinkOut

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