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    TBC1D5 TBC1 domain family member 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41628, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TBC1D5provided by FlyBase
    Official Full Name
    TBC1 domain family member 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0038129
    Locus tag
    Dmel_CG8449
    See related
    AllianceGenome:FB:FBgn0038129
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8449; Dmel\CG8449
    Summary
    Enables small GTPase binding activity. Predicted to be involved in retrograde transport, endosome to Golgi. Located in Golgi apparatus. Is expressed in adult fat body and organism. Orthologous to human TBC1D5 (TBC1 domain family member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See TBC1D5 in Genome Data Viewer
    Location:
    87E3-87E3; 3-53 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13269137..13272011, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9094859..9097733, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Suppressor of variegation 3-7 Neighboring gene ravus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new gene in Drosophila melanogaster, Ravus, the phantom of the modifier of position-effect variegation Su(var)3-7. Delattre M, et al. Int J Dev Biol, 2002 Jan. PMID 11902679
    2. Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain. Ye H, et al. Elife, 2020 Apr 14. PMID 32286230, Free PMC Article
    3. Identification of transcriptional targets of the dual-function transcription factor/phosphatase eyes absent. Jemc J, et al. Dev Biol, 2007 Oct 15. PMID 17714699, Free PMC Article
    4. GTPase-activating protein TBC1D5 coordinates with retromer to constrain synaptic growth by inhibiting BMP signaling. Zhou X, et al. J Genet Genomics, 2023 Mar. PMID 36473687
    5. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of retromer complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 5
    Names
    CG8449-PA
    TBC1D5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13269137..13272011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169499.2 → NP_731780.1  TBC1 domain family member 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731780.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFX6
      Related
      FBpp0082246
      Conserved Domains (1) summary
      smart00164
      Location:150 → 369
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95RV7 Q95RV7
    Q9VFX6 Q9VFX6

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