Rab7 Rab7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab7provided by FlyBase
Official Full Name: Rab7provided by FlyBase
Primary source: FLYBASE:FBgn0015795
Locus tag: Dmel_CG5915
See related: AllianceGenome:FB:FBgn0015795
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AAF56218; CG5915; Dm Rab7; Dmel\CG5915; DmRab7; drab7; dRab7; Drab7; DRab7; DRAB7; O76742; Rab-7; Rab-r7; rab7; RAB7; Rab7A
Summary: Predicted to enable GTPase activity. Involved in several processes, including T-tubule organization; endosomal transport; and vesicle fusion. Located in cell cortex and late endosome membrane. Is expressed in several structures, including adult ensheathing glial cell; brain; imaginal disc; mushroom body; and synaptic neuropil domain. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B. Orthologous to human RAB7A (RAB7A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 95D5-95D5; 3-82 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23993008..23995452)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (19818730..19821174)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy.
Title: Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy.
Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction.
Title: Drosophila Mon1 and Rab7 interact to regulate glutamate receptor levels at the neuromuscular junction.
Vps54 regulates Drosophila neuromuscular junction development and interacts genetically with Rab7 to control composition of the postsynaptic density.
Title: Vps54 regulates Drosophila neuromuscular junction development and interacts genetically with Rab7 to control composition of the postsynaptic density.
Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
Title: Regulation of NOTCH signaling by RAB7 and RAB8 requires carboxyl methylation by ICMT.
findings are not consistent with a gain-of-function mechanism. Instead, they indicate a dosage-dependent sensitivity of neurons to rab7-dependent degradation
Title: Charcot-Marie-Tooth 2B mutations in rab7 cause dosage-dependent neurodegeneration due to partial loss of function.
Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila.
Title: Dmon1 controls recruitment of Rab7 to maturing endosomes in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in border follicle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent endocytosis involved in vitellogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	TAS Traceable Author Statement more info	PubMed
involved_in endosomal vesicle fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endosome to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endosome to lysosome transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to lysosome transport	TAS Traceable Author Statement more info	PubMed
involved_in endosome to lysosome transport via multivesicular body sorting pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome-lysosome fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in secretory granule-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in wing disc dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	HDA more info	PubMed
is_active_in phagocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	HDA more info	PubMed
located_in synapse	HDA more info	PubMed
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Rab7

Names: CG5915-PA; CG5915-PB; CG5915-PC; Rab-protein 7; Rab7-PA; Rab7-PB; Rab7-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23993008..23995452

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079748.4 → NP_524472.1 Rab7, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524472.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76742

Related

FBpp0083891

Conserved Domains (2) summary

smart00175
Location:9 → 174

RAB; Rab subfamily of small GTPases

cd01862
Location:9 → 179

Rab7; Rab GTPase family 7 (Rab7)
NM_001260348.2 → NP_001247277.1 Rab7, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247277.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76742

Conserved Domains (2) summary

smart00175
Location:9 → 174

RAB; Rab subfamily of small GTPases

cd01862
Location:9 → 179

Rab7; Rab GTPase family 7 (Rab7)
NM_001260347.1 → NP_001247276.1 Rab7, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247276.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O76742

Conserved Domains (2) summary

smart00175
Location:9 → 174

RAB; Rab subfamily of small GTPases

cd01862
Location:9 → 179

Rab7; Rab GTPase family 7 (Rab7)