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    Nup107 Nucleoporin 107kD [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34481, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nup107provided by FlyBase
    Official Full Name
    Nucleoporin 107kDprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027868
    Locus tag
    Dmel_CG6743
    See related
    AllianceGenome:FB:FBgn0027868
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD18761; CG6743; Dmel\CG6743; dmNup107; Nup; Nup 107; nup107; Nup170
    Summary
    Enables chromatin binding activity. Involved in several processes, including meiotic cytokinesis; protein import into nucleus; and spermatocyte division. Located in nuclear envelope and nuclear periphery. Part of nuclear pore. Is expressed in several structures, including Malpighian tubule primordium; adult head; central brain primordium; embryonic/larval midgut primordium; and gut section. Used to study 46 XX gonadal dysgenesis and ovarian dysgenesis 6. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome; nephrotic syndrome type 11; and ovarian dysgenesis 6. Orthologous to human NUP107 (nucleoporin 107). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nup107 in Genome Data Viewer
    Location:
    32A5-32A5; 2-43 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10733293..10736071, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10733293..10736071, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ER membrane protein complex subunit 3 Neighboring gene Dpy-30-like 1 Neighboring gene Vacuolar H[+] ATPase 16kD subunit 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Postmitotic annulate lamellae assembly contributes to nuclear envelope reconstitution in daughter cells. Ren H, et al. J Biol Chem, 2019 Jul 5. PMID 31152066, Free PMC Article
    2. Efficient In Vivo Introduction of Point Mutations Using ssODN and a Co-CRISPR Approach. Levi T, et al. Biol Proced Online, 2020. PMID 32684853, Free PMC Article
    3. Nup153 is not required for anchoring heterochromatic DSBs to the nuclear periphery. Ryu T, et al. MicroPubl Biol, 2024. PMID 38737725, Free PMC Article
    4. Live imaging of bicoid-dependent transcription in Drosophila embryos. Lucas T, et al. Curr Biol, 2013 Nov 4. PMID 24139736
    5. A mutation in the nucleoporin-107 gene causes XX gonadal dysgenesis. Weinberg-Shukron A, et al. J Clin Invest, 2015 Nov 2. PMID 26485283, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eggshell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in male meiosis cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiosis I cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatocyte division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore outer ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore outer ring ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nucleoporin 107kD
    Names
    CG6743-PA
    Nup107-PA
    Nup170
    nucleoporin 107

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      10733293..10736071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135602.4 → NP_609446.1  nucleoporin 107kD [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609446.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V466
      UniProtKB/TrEMBL
      A1YK61
      Related
      FBpp0079710
      Conserved Domains (1) summary
      pfam04121
      Location:121 → 828
      Nup84_Nup100; Nuclear pore protein 84 / 107
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1YK54 A1YK54
    A1YK55 A1YK55
    A1YK56 A1YK56
    A1YK57 A1YK57
    A1YK58 A1YK58
    A1YK59 A1YK59
    A1YK60 A1YK60
    A1YK61 A1YK61
    A1YK62 A1YK62
    A1YK63 A1YK63
    A1YK65 A1YK65
    Q9V466.1 Q9V466

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