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    Ndg Nidogen [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36089, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndgprovided by FlyBase
    Official Full Name
    Nidogenprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026403
    Locus tag
    Dmel_CG12908
    See related
    AllianceGenome:FB:FBgn0026403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:CK00552; CG12908; CT32053; Dmel\CG12908; ndg
    Summary
    An extracellular matrix structural constituent. Involved in basement membrane assembly involved in embryonic body morphogenesis and regulation of basement membrane organization. Located in basement membrane. Is expressed in several structures, including embryonic myoblast; ganglia; mesoderm; muscle cell; and visceral mesoderm derivative. Orthologous to several human genes including NID1 (nidogen 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Ndg in Genome Data Viewer
    Location:
    47A1-47A1; 2-62 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10313891..10322104)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6201396..6209609)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Odorant-binding protein 46a Neighboring gene uncharacterized protein Neighboring gene slowpoke 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interommatidial cells build a tensile collagen network during Drosophila retinal morphogenesis. Ready DF, et al. Curr Biol, 2023 Jun 5. PMID 37209679, Free PMC Article
    2. A scar-like lesion is apparent in basement membrane after wound repair in vivo. Ramos-Lewis W, et al. Matrix Biol, 2018 Dec. PMID 29981372, Free PMC Article
    3. Evidence of Swim secretion and association with extracellular matrix in the Drosophila embryo. Kaltezioti V, et al. Int J Dev Biol, 2022. PMID 34881800
    4. Distinct contributions of ECM proteins to basement membrane mechanical properties in Drosophila. Töpfer U, et al. Development, 2022 May 15. PMID 35575071
    5. Characterization of Drosophila Nidogen/entactin reveals roles in basement membrane stability, barrier function and nervous system patterning. Wolfstetter G, et al. Development, 2019 Jan 16. PMID 30567930

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NDG is not essential for basement (BM) assembly but mediates BM stability and extracellular matrix-dependent neural plasticity during Drosophila development.
      Title: Characterization of Drosophila Nidogen/entactin reveals roles in basement membrane stability, barrier function and nervous system patterning.
    2. Study show that in the Drosophila, Ndg is dispensable for basement membrane assembly and preservation in many tissues, but absolutely required in others.
      Title: Dissection of Nidogen function in Drosophila reveals tissue-specific mechanisms of basement membrane assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables extracellular matrix structural constituent IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in basement membrane assembly involved in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basement membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nidogen
    Names
    CG12908-PA
    CG12908-PC
    Ndg-PA
    Ndg-PC
    Nidogen-like
    nidogen/entactin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10313891..10322104
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206074.2 → NP_995796.2  nidogen, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995796.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z876, A1Z877, B7FNR1
      Conserved Domains (8) summary
      smart00135
      Location:1152 → 1195
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00539
      Location:108 → 262
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      smart00682
      Location:322 → 549
      G2F; G2 nidogen domain and fibulin
      cd05819
      Location:1067 → 1103
      NHL; NHL repeat [structural motif]
      cl18310
      Location:1059 → 1275
      NHL; NHL repeat unit of beta-propeller proteins
      pfam07645
      Location:591 → 627
      EGF_CA; Calcium-binding EGF domain
      pfam12947
      Location:1001 → 1036
      EGF_3; EGF domain
      cl39070
      Location:1084 → 1123
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B

    2. NM_136731.2 → NP_610575.1  nidogen, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610575.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z876, A1Z877, B7FNR1
      Related
      FBpp0087438
      Conserved Domains (8) summary
      smart00135
      Location:1152 → 1195
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00539
      Location:108 → 262
      NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
      smart00682
      Location:322 → 549
      G2F; G2 nidogen domain and fibulin
      cd05819
      Location:1067 → 1103
      NHL; NHL repeat [structural motif]
      cl18310
      Location:1059 → 1275
      NHL; NHL repeat unit of beta-propeller proteins
      pfam07645
      Location:591 → 627
      EGF_CA; Calcium-binding EGF domain
      pfam12947
      Location:1001 → 1036
      EGF_3; EGF domain
      cl39070
      Location:1084 → 1123
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z877.1 A1Z877

    Gene LinkOut

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