U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Vap33 VAMP-associated protein 33kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31349, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vap33provided by FlyBase
    Official Full Name
    VAMP-associated protein 33kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029687
    Locus tag
    Dmel_CG5014
    See related
    AllianceGenome:FB:FBgn0029687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-2.42; anon-WO03040301.124; BcDNA:GM03307; CG5014; clone 2.42; Dmel\CG5014; dvap; dVAP; DVAP; dVAP-33; DVAP-33A; dVAP-A; dvap33a; dVAP33A; DVAP33A; l(1)G0231; VAP; VAP-33; Vap-33-1; VAP-33-1; vap-33A; Vap-33A; vap33; VAP33; vap33-1; Vap33-1; VAP33-A; VAP33A; vapb; VAPB
    Summary
    Predicted to enable protein-membrane adaptor activity. Involved in several processes, including cytoplasmic microtubule organization; defense response to Gram-negative bacterium; and synapse organization. Located in endoplasmic reticulum; extracellular space; and plasma membrane. Is active in several cellular components, including cholinergic synapse; presynaptic cytoskeleton; and presynaptic membrane. Is expressed in adult head; adult heart; and organism. Used to study amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; motor neuron disease; and neurodegenerative disease. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 8; autosomal dominant adult-onset proximal spinal muscular atrophy; and spinal muscular atrophy. Orthologous to several human genes including VAPB (VAMP associated protein B and C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Vap33 in Genome Data Viewer
    Location:
    3F9-3F9; 1-5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3948975..3955442)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3843008..3849475)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Gemin 4b Neighboring gene Gemin 4c Neighboring gene lava lamp Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cholinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    VAMP-associated protein 33kDa
    Names
    CG5014-PA
    CG5014-PB
    CG5014-PC
    CG5014-PE
    VAMP-associated protein of 33kDa A
    VAMP-associated protein of 33kDa ortholog A
    Vap-33-1
    Vap33-1
    Vap33-PA
    Vap33-PB
    Vap33-PC
    Vap33-PE

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      3948975..3955442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206623.2NP_996346.2  VAMP-associated protein 33kDa, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996346.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVX4, Q9W4N8
      Conserved Domains (1) summary
      pfam00635
      Location:9115
      Motile_Sperm; MSP (Major sperm protein) domain
    2. NM_130731.3NP_570087.1  VAMP-associated protein 33kDa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_570087.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVX4, Q9W4N8
      Related
      FBpp0070589
      Conserved Domains (1) summary
      pfam00635
      Location:9115
      Motile_Sperm; MSP (Major sperm protein) domain
    3. NM_206625.2NP_996348.1  VAMP-associated protein 33kDa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVX5
      Conserved Domains (1) summary
      pfam00635
      Location:9115
      Motile_Sperm; MSP (Major sperm protein) domain
    4. NM_206624.2NP_996347.1  VAMP-associated protein 33kDa, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVX4, Q9W4N8
      Conserved Domains (1) summary
      pfam00635
      Location:9115
      Motile_Sperm; MSP (Major sperm protein) domain