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    vir virilizer [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47869, updated on 9-Dec-2024

    Summary

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    Official Symbol
    virprovided by FlyBase
    Official Full Name
    virilizerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003977
    Locus tag
    Dmel_CG3496
    See related
    AllianceGenome:FB:FBgn0003977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3496; Dmel\CG3496; Vir
    Summary
    Involved in several processes, including positive regulation of border follicle cell migration; primary sex determination, soma; and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in organism. Orthologous to human VIRMA (vir like m6A methyltransferase associated). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See vir in Genome Data Viewer
    Location:
    59D8-59D9; 2-102 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23360192..23366355, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19247715..19253878, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44168 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Methenyltetrahydrofolate synthetase Neighboring gene Interacts with the C terminus of ELL 1 Neighboring gene Golgin-245 Neighboring gene uncharacterized protein Neighboring gene yellow-d

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sex-determining gene tra-2 of Drosophila encodes a putative RNA binding protein. Amrein H, et al. Cell, 1988 Dec 23. PMID 3144434
    2. Molecular identification of virilizer, a gene required for the expression of the sex-determining gene Sex-lethal in Drosophila melanogaster. Niessen M, et al. Genetics, 2001 Feb. PMID 11156988, Free PMC Article
    3. Control of oocyte maturation in sexually mature Drosophila females. Soller M, et al. Dev Biol, 1999 Apr 15. PMID 10191049
    4. virilizer regulates Sex-lethal in the germline of Drosophila melanogaster. SchüŁtt C, et al. Development, 1998 Apr. PMID 9502731
    5. The temperature-sensitive mutation vir (ts)(virilizer) identifies a new gene involved in sex determination of Drosophila. Hilfiker A, et al. Rouxs Arch Dev Biol, 1991 Nov. PMID 28305793

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing, via transesterification reactions IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary sex determination, soma IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sex-chromosome dosage compensation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA N6-methyladenosine methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    virilizer
    Names
    CG3496-PA
    vir-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23360192..23366355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080161.2 → NP_524900.1  virilizer [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524900.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W1R5
      Related
      FBpp0071946
      Conserved Domains (1) summary
      pfam15912
      Location:6 → 263
      VIR_N; Virilizer, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1R5.1 Q9W1R5

    Gene LinkOut

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