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    scrt scratch [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38469, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scrtprovided by FlyBase
    Official Full Name
    scratchprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004880
    Locus tag
    Dmel_CG1130
    See related
    AllianceGenome:FB:FBgn0004880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.31; anon-EST:Liang-1.67; anon-WO02059370.57; BcDNA:RH71479; CG1130; clone 1.31; clone 1.67; Dmel\CG1130; lincRNA.S4061; Scrt
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including ganglia; imaginal disc; sensory nervous system primordium; sensory neurons; and somatic precursor cell. Orthologous to human SCRT1 (scratch family transcriptional repressor 1) and SCRT2 (scratch family transcriptional repressor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See scrt in Genome Data Viewer
    Location:
    64A2-64A3; 3-10 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3983896..3994003)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3983896..3994003)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Forkhead box L1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved by repression. Emery JF, et al. Development, 1995 Nov. PMID 8582269
    2. McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes. Hafez D, et al. Genome Biol, 2017 Oct 26. PMID 29070071, Free PMC Article
    3. A sensory feedback circuit coordinates muscle activity in Drosophila. Hughes CL, et al. Mol Cell Neurosci, 2007 Jun. PMID 17498969, Free PMC Article
    4. The increasing complexity of the Snail gene superfamily in metazoan evolution. Manzanares M, et al. Trends Genet, 2001 Apr. PMID 11275308
    5. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Barrallo-Gimeno A, et al. Development, 2005 Jul. PMID 15983400

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    scratch
    Names
    CG1130-PA
    CG1130-PB
    scrt-PA
    scrt-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3983896..3994003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274461.1 → NP_001261390.1  scratch, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261390.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24140, Q9VZK2, Q9Y144
      Conserved Domains (5) summary
      COG5048
      Location:520 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:526 → 546
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:554 → 574
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:566 → 590
      zf-H2C2_2; Zinc-finger double domain

    2. NM_079187.5 → NP_523911.2  scratch, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523911.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q24140, Q9VZK2, Q9Y144
      Related
      FBpp0073022
      Conserved Domains (5) summary
      COG5048
      Location:520 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:526 → 546
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:469 → 489
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:554 → 574
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:566 → 590
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24140 Q24140
    Q7KMM2 Q7KMM2
    Q86P75 Q86P75
    Q9VZK2 Q9VZK2

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