Phb1 Prohibitin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Phb1provided by FlyBase
Official Full Name: Prohibitin 1provided by FlyBase
Primary source: FLYBASE:FBgn0002031
Locus tag: Dmel_CG10691
See related: AllianceGenome:FB:FBgn0002031
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cc; CG10691; Dmel\CG10691; fs(2)HH32; l (2) 37Cc; l(2)37Cc; l(2)Cc
Summary: Involved in cellular response to hypoxia. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelial cell; gut section; and larval muscle cell. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19121345..19123869, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19121345..19123869, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial prohibitin complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

Names: CG10691-PA; CG10691-PB; CG10691-PD; Phb1-PA; Phb1-PB; Phb1-PD; lethal (2) 37Cc; transcription unit No. 4

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The following sections contain reference sequences that belong to a specific genome build. Explain