LamC Lamin C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: LamCprovided by FlyBase
Official Full Name: Lamin Cprovided by FlyBase
Primary source: FLYBASE:FBgn0010397
Locus tag: Dmel_CG10119
See related: AllianceGenome:FB:FBgn0010397
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10119; DmC; Dmel\CG10119; G-IF; lamC; LAMC; lamin C; pG-IF
Summary: A structural constituent of cytoskeleton. Involved in several processes, including male meiosis cytokinesis; nuclear pore localization; and regulation of actin filament polymerization. Located in lamin filament and spindle envelope. Colocalizes with nuclear envelope. Is expressed in several structures, including germline cell; gut section; oenocyte; somatic cell of ovariole; and somatic cell of testis. Used to study dilated cardiomyopathy 1A; familial partial lipodystrophy type 2; myopathy (multiple); and progeria. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); neuromuscular disease (multiple); and type 2 diabetes mellitus (multiple). Orthologous to human LMNA (lamin A/C); LMNB1 (lamin B1); and LMNB2 (lamin B2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 51B1-51B1; 2-72 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14570810..14575771, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10458315..10463276, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lamin C, the sole A-type lamin in Drosophila, contributes to the process of thorax closure in pupa.
Title: High expression of A-type lamin in the leading front is required for Drosophila thorax closure.
Human progeroid syndrome-modeled LamC mutations induced premature aging in adult flight muscles, including decreased levels of specific mitochondrial protein transcripts (RNA) and progressive mitochondrial degradation. They also induced the accelerated appearance of other phenotypes associated with aging.
Title: Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding.
The critical function of A-type lamin C proteins in Drosophila musculature is to maintain proper function and morphology of tendon cells.
Title: Loss of Drosophila A-type lamin C initially causes tendon abnormality including disintegration of cytoskeleton and nuclear lamina in muscular defects.
of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C
Title: The different function of single phosphorylation sites of Drosophila melanogaster lamin Dm and lamin C.
Study finds that C-terminal fragments of DFz2 accumulate in nuclear foci in association with large RNA granules localizing to the space between the inner
Title: Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signaling.
Drosophila lamC has a tissue-specific role during development and is required for chromatin organization.
Title: Lamin C and chromatin organization in Drosophila.
larval muscle-specific expression of a truncated form of Lamin C lacking the N-terminal head (Lamin C DeltaN) caused muscle defects and semi-lethality, with adult 'escapers' possessing malformed legs.
Title: The role of Drosophila Lamin C in muscle function and gene expression.
Data provide the first detailed genetic analysis of the LamC gene and support using Drosophila as a model to study the role of lamins in disease.
Title: Molecular genetic analysis of the nested Drosophila melanogaster lamin C gene.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear envelope organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lamin filament	IDA Inferred from Direct Assay more info	PubMed
located_in lamin filament	NAS Non-traceable Author Statement more info	PubMed
colocalizes_with nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear lamina	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear lamina	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in spindle envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: lamin C

Names: CG10119-PA; CG10119-PB; G intermediate filament; LamC-PA; LamC-PB; Lamin-C; LaminC; lamin; lamin A; lamin DmC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

14570810..14575771 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079018.3 → NP_523742.2 lamin C, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523742.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q03427, Q24374, Q9V729

Related

FBpp0086641

Conserved Domains (4) summary

pfam00038
Location:45 → 401

Filament; Intermediate filament protein

pfam00932
Location:473 → 578

LTD; Lamin Tail Domain

cl19252
Location:178 → 224

MreC; rod shape-determining protein MreC

cl21478
Location:67 → 142

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001274045.1 → NP_001260974.1 lamin C, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260974.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFY9

Conserved Domains (4) summary

pfam00038
Location:45 → 401

Filament; Intermediate filament protein

pfam00932
Location:473 → 574

LTD; Lamin Tail Domain

cl19252
Location:178 → 224

MreC; rod shape-determining protein MreC

cl21478
Location:67 → 142

ATP-synt_B; ATP synthase B/B' CF(0)